Omphalotin A, a cyclic dodecapeptide produced by submerged cultures of the basidiomycete Omphalotus olearius, exhibited in-vitro and in-vivo nematicidal activity. Meloidogyne incognita was the most sensitive nematode. At 2.0 mg litre-1, 50% of the nematodes were dead after one hour. Heterodera schachtii, Radopholus similis and Pratylenchus penetrans were aþ ected at higher concentrations. Incorporated into agar, the compound prevented infection of cucumber seedlings by M. incognita at concentrations of 1 mg litre-1 and higher. In glasshouse tests, complete protection of cucumbers and lettuce was achieved between 2.5 and 10 mg litre-1. No insecticidal activity was observed when Plutella xylostella, Phaedon cochleariae or Spodoptera frugiperda were fed material containing 4 g kg-1 of omphalotin A. 1999 Society of Chemical Industry (
This study investigates the use of novel manufacturing technologies for space antenna feed chain systems. A comparison between conventional and advanced manufacturing technologies concerning the radio‐frequency (RF) performance was made, in order to derive design rules for the novel manufacturing technology. Waveguide runs as well as feed chain components were redesigned by using these design rules. Therefore, mainly elliptical and circular waveguide sections were used. Different components were combined to save mass and power losses. Additive layer manufacturing (ALM) was chosen to build feed chain components in order to investigate the advantages of ALM compared to conventional technologies. This study concludes with an outlook on future opportunities of advanced manufacturing technologies for RF space applications as well as ongoing development activities.
Background
Avoiding or correcting a diagnostic error first requires identification of an error and perhaps deciding to revise a diagnosis, but little is known about the factors that lead to revision. Three aspects of reflective practice, seeking Alternative explanations, exploring the Consequences of missing these alternative diagnoses, identifying Traits that may contradict the provisional diagnosis, were incorporated into a three-point diagnostic checklist (abbreviated to ACT).
Methods
Seventeen first and second year emergency medicine residents from the University of Toronto participated. Participants read up to eight case vignettes and completed the ACT diagnostic checklist. Provisional and final diagnoses and all responses for alternatives, consequences, and traits were individually scored as correct or incorrect. Additionally, each consequence was scored on a severity scale from 0 (not severe) to 3 (very severe). Average scores for alternatives, consequences, and traits and the severity rating for each consequence were entered into a binary logistic regression analysis with the outcome of revised or retained provisional diagnosis.
Results
Only 13% of diagnoses were revised. The binary logistic regression revealed that three scores derived from the ACT tool responses were associated with the decision to revise: severity rating of the consequence for missing the provisional diagnosis, the percent correct for identifying consequences, and the percent correct for identifying traits (χ2 = 23.5, df = 6, p < 0.001). The other three factors were not significant predictors.
Conclusions
Decisions to revise diagnoses may be cued by the detection of contradictory evidence. Education interventions may be more effective at reducing diagnostic error by targeting the ability to detect contradictory information within patient cases.
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