A b s t r a c tIntroduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, with a significant effect on quality of life (QoL). Aim: To evaluate the impact of AD on QoL of Montenegrin infants and their parents and to identify predictors affecting their QoL. Material and methods: The cross-sectional study was conducted between August 2017 and July 2018 and included 186 infants with AD aged 0-4 years and their parents. The severity of disease was measured by the Three-Item Severity (TIS) score, while QoL was assessed with the Infants' Dermatitis Quality of Life Index (IDQOL) and the Dermatitis Family Impact (DFI) questionnaire. Results: The mean overall scores were 14.72 for IDQOL and 17.78 for DFI. The positive correlation was observed between AD severity and both the IDQOL and DFI scores (r = 0.61, p < 0.001 and r = 0.67, p < 0.001, respectively). The highest-scoring IDQOL items were "itching and scratching", and "child's mood". Poorer infants' QoL was associated with more serious AD (B = 2.56; 95% confidence interval (CI): 2.08-3.04), concomitant atopic disease (B = 3.86; 95% CI: 1.78-5.94), family history of atopic disease (B = 3.80; 95% CI: 1.84-5.77), older age of the child (B = 1.14; 95% CI: 0.20-2.07) and older age of the parent (B = 0.28; 95% CI: 0.04-0.53). Similarly, parents had poorer QoL if their infants had more severe AD (B = 2.56; 95% CI: 2.14-2.87), another atopic disease (B = 2.91; 95% CI: 0.99-4.84) or family history of atopic disease (B = 4.33; 95% CI: 2.57-6.09). Conclusions: Our results demonstrate that AD has a significant negative impact on infants' QoL as well as on QoL of their parents.

Background/Aim. Nowadays, low birth weight is considered to be one of the main causes of cardiovascular diseases or metabolic syndrome occurring later in life. Many studies have shown a strong impact of abnormal birth weight onto the future development, however, due to its stronger influence onto the development, a special emphasis is placed on low birth weight as compared to higher one. There is still no high-percentage accuracy test that will clearly classify expectant women under the risk of giving birth to a child too low or too big for gestational age. The aim of this paper was to set up a model that may indicate future low or high birth weight. Methods. This study included 191 expectant women who were divided into three groups, based on the birth weight (group 1: ? 3,000 g; group 2: 3,000?4,000 g; group 3: ? 4,000 g). The values of biochemical (pregnancy associated plasma protein A ? PAPP-A, free ? human chorionic gonadotropin) and ultra-sonographic markers (nuchal translucency) as well as their multiple of the median (MoM) were determined and com-pared among groups. Results. It was shown that the values of PAPP-A MoM were considerably lower in groups of expectant women that had a fetus with low body weight (p = 0.003, p = 0.001). Statistically significant correlation between PAPP-A MoM and the newborn?s weight (rs = 0.221, p = 0.001) was proven among the groups examined within this study. Conclusion. The usage of a combination of biochemical parameters, sonographic and demographic data in screening program increases the chances for early identification of fetuses that are under higher risk for growth restriction or increased growth. Al-so, the increase in the value of PAPP- A MoM causes the increase of fetus? body weight.

Objective: HIV/AIDS represents a significant public health issue since the number of cases is continuously on the rise. Even though contemporary medicine is rapidly developing, there is currently no effective cure for HIV. Mucocutaneous manifestations often represent the first recognized clinical manifestation. This study was carried out to note different presentations of HIV/AIDS on the skin. Material and Methods: The study included 150 patients who were hospitalized and have been confirmed as HIV positive either before the hospitalization or during the hospitalization. Results: Out of 150 patients, 50 of them had mucocutaneous presentations. Frequently, mucocutaneous lesions are the first manifestation of HIV/AIDS and a pointer toward setting up HIV/AIDS diagnosis. Moreover, the same patient was admitted more than once, because of a variety of skin manifestations. Conclusion: It was recognized that the greater the destruction of the immune system is, the more severe forms of mucocutaneous diseases occur. It is considered that cutaneous manifestations are rarely considered life-threatening in people living with HIV, but they can undoubtedly impair their quality of life.