Introduction: The problem related to water pollution of nitrates and nitrites is both an issue in Iran and also most parts of the world. Studies to evaluate the acute and chronic effects of nitrate and nitrite have demonstrated that different concentrations of these compounds in water and food have been causing multiple diseases. Methods: In this paper, researchers reviewed published articles and research from 1950 to 2016 in English and Farsi, according to key words "nitrate", "nitrite", "water", "food" and "health effects", retrieved from databases, such as Medline, Scopus, Pub Med, and scientific information database (SID). Results: Consumption of drinking water and food containing high concentrations of nitrate and nitrite could cause diseases, such as cancer, methemoglobinemia, and enlargement of the thyroid gland and diabetes mellitus. The positive effects of low concentrations of nitrates and nitrites include a protective effect on the cardiovascular system, regulatory role in blood pressure, and homeostasis (also static) of the vessels Conclusions: As different concentrations of nitrates and nitrites have beneficial and undesirable effects on human health and regarding the high cost of treating water contaminated with nitrite and nitrate, more investigations should be done in setting the standards and levels of parameters used in drinking water.

Background. Regarding the lack of comprehensive systematic review on the efficacy of water fluoridation and prevalence of dental fluorosis, the aim of the current research was to systematically study the prevalence of dental fluorosis at different levels of water fluoride in the world and lay emphasis on the amount of fluoride in drinking water.Methods. Studies were searched in PubMed, Scopus, SID, and IranMedex, with regard to inclusion criteria. Study validity was assessed with some checklists, and analyses were performed to ascertain the prevalence of dental fluorosis among individuals categorized in age groups.Results. Investigation of the heterogeneity and analysis of the subgroups revealed that in the 6-18 year age group, when water fluoride level was less than 0.7 ppm and there was exposure to water fluoride in the first 6-8 years of life, no significant heterogeneity was detected among the studies in this subgroup. Thus, the pooled estimation of dental fluorosis prevalence in this subgroup was 12.9% (95% CI: 7.5-18.3%). Furthermore, meta-regression indicated that the exposure time to fluoride in drinking water, or exposure to fluoride in supplements, diets, air, etc as well as the quality of studies had a significant relation to the difference in the prevalence of dental fluorosis.Conclusion. The results revealed no heterogeneity in just 2 subgroups, and the results of subgroups could be pooled in them. Furthermore, the number of studies included in this review considerably decreased by considering all the detected confounding factors, whereas other similar systematic reviews mentioned at most 2 factors.

Nitrate is a common contaminant of drinking water. Due to its adverse health effects, this study aimed to determine nitrate levels in six southern districts of Tehran. A total of 148 samples were taken from tap waters. In 84.46% (n = 125) of the samples, the nitrate concentration was below national and WHO limits (50 mg/L); however, 15.54% (n = 23) were in violation of the criteria. The total mean concentration of nitrate was 36.15 mg/L (±14.74) ranging from 4.52 to 80.83 mg/L. The overall hazard quotient (HQ) for age groups were ordered as Children (1.71) > Infants (1.24) > Teenagers (1.2) > Adults (0.96). In all districts, the HQ values for infants and children groups were greater than 1, indicating potential adverse health risks. In teenagers age group, only the HQ estimations of districts 10 (HQ = 0.93) and 11 (HQ = 0.74) were lower than 1 and in adults age group, the estimated HQ values for districts were lower than 1 with the exception for district 19 (HQ = 1.19). The sensitivity analysis (SA) showed that nitrate content plays a major role in the value of the assessed risk.

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