Glial cells comprise the non-sensory parts of the central nervous system as well as the peripheral nervous system. Glial cells, also known as neuroglia, constitute a significant portion of the mammalian nervous system and can be viewed simply as a matrix of neural cells. Despite being the “Nervenkitt” or “glue of the nerves”, they aptly serve multiple roles, including neuron repair, myelin sheath formation, and cerebrospinal fluid circulation. Ependymal cells are one of four kinds of glial cells that exert distinct functions. Tumorigenesis of a glial cell is termed a glioma, and in the case of an ependymal cell, it is called an ependymoma. Among the various gliomas, an ependymoma in children is one of the more challenging brain tumors to cure. Children are afflicted more severely by ependymal tumors than adults. It has appeared from several surveys that ependymoma comprises approximately six to ten percent of all tumors in children. Presently, the surgical removal of the tumor is considered a standard treatment for ependymomas. It has been conspicuously evident that a combination of irradiation therapy and surgery is much more efficacious in treating ependymomas. The main purpose of this review is to present the importance of both a deep understanding and ongoing research into histopathological features and prognoses of ependymomas to ensure that effective diagnostic methods and treatments can be developed.

<p>Withania somnifera, known as Aswogondha in Bangladesh and some part of India, is a shrub of Solanceae family. Parts of this plant is used as alternative medicine in this region to cure diseases from bronchitis to insomnia. Although such use of the plant is not supported by clinical research, recent studies have found anticancer activity of some proteins derived from w. somnifera. The purpose of this study is to summarize the anticancer activity of medicinal plant Withania somnifera and its bioactive compounds as well as to predict the interaction between phytochemicals (Withanolide, Withaferin-A) and macromolecules that are responsible for cancer cell proliferation. Studies suggested that Withanolide and Withaferin-A from W. somnifera can be used as a cancer chemotherapeutic agent for cancerous cell lines in mice models through modulating various signaling pathway including inhibition, autophagy, apoptosis, radiopreventive pathway and reactive oxygen species pathway. Molecular docking of Withanolide and Withaferin-A against 9 types of vital protein mediators concluded that 3A8X (Protein kinase C iota type) and 1A9U (MAP KINASE P38) are the most active receptor for binding and interacting with Withanolide and Withaferin-A for the prevention and treatment of cancer. On the basis of this review and docking study, it can be concluded that Withania somnifera as well as its derivatives Withanolide and Withaferin-A may be considered as a promising anticancer agent. </p>

<div>Coronavirus (COVID-19) mediated infection is a highly contagious respiratory illness that was initially found in Wuhan city of Hubei Province in China. The ongoing pandemic of the novel SARS-CoV-2 virus is affecting global health. Despite the recent success in vaccination on a trial basis, there is no treatment of the infection. Thus, establishing an effective therapeutic measure is of apex priority among biologists and healthcare professionals. Re-purposing Remdesivir, a broad-spectrum antiviral agent that inhibits viral RNA polymerase, has been found effective for the treatment of COVID-19. In this study, modification of the existing drug Remdesivir was done. In logical drug designing and development, molecular recognition plays a central role in this sphere. The anti viral function of Remdesivir is achieved by binding to RNA polymerase enzyme. The protein 7BTF is an RNA-dependent RNA polymerase that plays a crucial role in coronavirus replication and transcription machinery and it appears to be the primary target of the antiviral drug Remdesivir. The study intend to design derivative compounds form Remdesivir to screen out the a better drug against the SARS-CoV-2 virus by inhibiting the targeted protein. The efficacy of these new drugs was also tested by molecular docking calculations. The drug derivatives were docked for binding affinity and non-bond interactions. Pharmacokinetic activities of the designed drugs are also predicted. All the drugs are non-carcinogenic and chemically reactive. In our study, modified compound D-I has exhibited the best performance among Remdesivir and it’s derivatives. This study might provide an insight into the potential of a Remdesivir derivative in treating SARS-CoV-2 infection<br></div>

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) is a causative agent of the potentially fatal coronavirus disease (COVID-19). Coronavirus targets the human respiratory system primarily. It can also infect the gastrointestinal, hepatic, and central nervous systems of humans, avians, bats, livestock, mice, and many other wild animals, as these are primary targets of the pathogen. This study aims to screen out the most potent inhibitor for SARS-CoV-2 (COVID-19) spike glycoproteins among the selected drugs, and computational tools have been utilized for this purpose. The selected drugs have been designed to explore their structural properties in this study by molecular orbital calculation. To inhibit the spike glycoproteins, the performance of these drugs was also examined by molecular docking calculation. In improving the performance of drugs, non-bond interactions play a significant role. To determine the chemical reactivity of all the medicines, HOMO and LUMO energy values were also calculated. The combined calculations exhibited that Ledipasvir among the selected drugs can be the most potent drug to treat SARS-CoV-2 compared to other medications.

<div>Coronavirus (COVID-19) mediated infection is a highly contagious respiratory illness that was initially found in Wuhan city of Hubei Province in China. The ongoing pandemic of the novel SARS-CoV-2 virus is affecting global health. Despite the recent success in vaccination on a trial basis, there is no treatment of the infection. Thus, establishing an effective therapeutic measure is of apex priority among biologists and healthcare professionals. Re-purposing Remdesivir, a broad-spectrum antiviral agent that inhibits viral RNA polymerase, has been found effective for the treatment of COVID-19. In this study, modification of the existing drug Remdesivir was done. In logical drug designing and development, molecular recognition plays a central role in this sphere. The anti viral function of Remdesivir is achieved by binding to RNA polymerase enzyme. The protein 7BTF is an RNA-dependent RNA polymerase that plays a crucial role in coronavirus replication and transcription machinery and it appears to be the primary target of the antiviral drug Remdesivir. The study intend to design derivative compounds form Remdesivir to screen out the a better drug against the SARS-CoV-2 virus by inhibiting the targeted protein. The efficacy of these new drugs was also tested by molecular docking calculations. The drug derivatives were docked for binding affinity and non-bond interactions. Pharmacokinetic activities of the designed drugs are also predicted. All the drugs are non-carcinogenic and chemically reactive. In our study, modified compound D-I has exhibited the best performance among Remdesivir and it’s derivatives. This study might provide an insight into the potential of a Remdesivir derivative in treating SARS-CoV-2 infection<br></div>