Objective:

Objective: This study was to investigate the increase of TIMP-1 gingival clavicular fluid ater application of rosella flower extract gel on gingiva as the standard treatment of gingivitis after acrylic crown insertion. Material and Methods: This research type was pure experimental research using randomized design pre-and post-t-test with control group (the randomized pretest-posttest control group design). Clinical test (in vivo test) were done to determine the effect gel therapeutic containing rosella extract as therapy on standards gingivitis treatment in patients with artificial crown. Results: Antimicrobial test of Rosella flower extract on P. gingivalis and S. Sanguis bacteria showed that antimicrobial effectiveness of Rosella flower extract was found at concentration of 10%. Conclusion: 10% rosella gel extracts can be used as an alternative ingredients in standard gingival inflammation treatment due to artificial acrylic crown using.

Objective: To compare the osteoblast cell formation process after installation implant with and without added of platelet-rich plasma (PRP). Methods: Twenty-four male rabbit were selected by purposive sampling, divide into two groups. Group 1 implant with added PRP were installation in the distal part of the thigh bone 12 male rabbits, Group 2 implants without the addition of PRP mounted on the distal part of the thigh bone 12 male rabbits. All rabbits in euthanasia after 0, 7, 14, and 28 days were then analyzed histologically to determine the formation of osteoblast cells. Results: There is increased formation of osteoblast cell formation in implant installation with the addition of PRP when compared with implants without PRP as time increases. Conclusion: Administration of PRP in implants can speed up and increase osteoblast cell formation.