Various ethnics of the world have a long history on using their surrounding as the source of foods. Foods which are act as product of traditional ethnic knowledge known as traditional and ethnic foods (TEF). Vegetables are one of the main ingredients of TEF. As sources of many combination of phytonutrients, vegetables offer various health benefits. As a country with long history of agricultural practice, Indonesia also has abundant knowledge of how Indonesian ethnics process and consume vegetables.Vegetables, in Sundanese tradition, usually consumed as “lalap” or “lalapan”. Some lalapan are cultivated vegetables and some others are come from wild sources. This article discuss the health benefits of wild source lalapan, which can be found in natural habitat.
Hair loss is a hair problem that often occurs in every individual. Side effects caused by the use of synthetic drugs cause herbal remedies to be an option in overcoming hair loss and to stimulate hair growth. Rampai leaves (Lycopersicon esculentum Mill.) has traditionally been used to stimulate hair growth in the Lampung tribe. This study aim was to examine the activity of hair growth stimulation effects of ethanol extract and fraction (n-hexane, ethyl acetate, and water) from rampai leaves. The activity test of hair growth stimulation effect was carried out topically on New Zealand White (NZW) male rabbits for 21 days with the modified Tanaka method and using 2% minoxidil as a positive control The analysis results were evaluated statistically. The test results of ethanol extract of rampai leaves showed the most significant hair growth stimulation activity at 10% concentration, followed by a concentration of 20% and 5%. In testing the activity of fraction, n-hexane fraction significantly showed better hair growth activity compared to ethyl acetate, water fractions, and positive control. This showed that rampai leaves had vity of hair growth stimulation effects could be used as anti-alopecia treatment. Further experiments are needed to find the chemical compound content that is responsible for the nature of hair growth.
AbstrakSenyawa triterpenoid damaran, damara-20,24-dien-3-on telah diisolasi dari kulit batang Chisocheton Marcrophyllus (Meliaceae). Struktur kimia kedua senyawa tersebut telah ditetapkan berdasarkan data spektroskopi dan perbandingan data spektra yang diperoleh dari literatur. Senyawa damara-20,24-dien-3-on menunjukkan aktivitas sitotoksik terhadap sel kanker payudara manusia MCF-7 dengan nilai IC50 28 mM.Kata Kunci : aktivitas sitotoksik, sel MCF-7, triterpenoid damaran, Chisocheton Marcrophyllus, MeliaceaeAbstractDammarane triterpenoid, damara-20,24-dien-3-on has been isolated from the bark of Chisocheton Marcrophyllus (Meliaceae). Chemical Structure of compound was dtermined on the basic of spektroscopic data and comparison with those spectra data previously reported. Compound damara-20,24-dien-3-on exhibited cytotoxic activity againts MCF-7 human breast cancer cell lines with IC50 value 28 mM respectively.Kata Kunci : cytotoxic activity, MCF-7 cell, dammarane triterpenoid, Chisocheton Marcrophyllus, Meliaceae
The pharmacological activities of Plecranthus sp include anti-oxidant, antimicrobial, inhibition on cyclooxygenase (COX) and xanthine oxidase, and cytotoxic activity. The aim of this work was to study the antipyretic activity of P. scutellarioides (L.) extract on animal model. Twenty seven Swiss Webster male mice were divided into nine groups and were pyrexia-induced by using 0.1 ml of diphteria-pertussis-tetanus (DPT) vaccine. Their body temperature was measured every 60 minutes. After 4 hours of DPT vaccine injection, the mice were treated with (I) Arabic gum suspension (PGA) 2%; (II) paracetamol 16.25 mg/kg BW; (III) paracetamol 32.5 mg/kg BW; (IV) paracetamol 65 mg/kg BW; (V) paracetamol 130 mg/kg BW; (VI) P. scutellarioides extract 70 mg/kg BW; (VII) P. scutellarioides extract 140 mg/kg BW; (VIII) P. scutellarioides extract 280 mg/kg BW; (IX) P. scutellarioides extract 560 mg/kg BW. Data were analyzed using SPSS 21. Result showed that the body temperature of the mice started to rise at 2.5 hours and reached its peak at 4 hours after vaccine induction. The P. scutellarioides extract dose 280 mg/kg of BW indicated an 80.47% decrease (α= 0.05) compared to paracetamol dose 130 mg/kg of BW which decreases 85.43% of the animals’ fever. Interestingly, higher dose of the extract indicated a decrease in the antipyretic effect. We concluded that P. scutellarioides might possess antipyretic activity which started as early as 5 hours post vaccine-induced and was maintained for 3 hours. This plant needs further scientific exploration Keywords: Diphteria-pertusis-tetanus vaccine, anti-pyretic, rectal temperature, Webster mice
Drugs consultation by pharmacist is an important service to improve the quality of medication use in patients with type 2 diabetes mellitus (T2DM). Perception of patients regarding this service is very useful to boost pharmacists confidence to conduct such service. The purpose of this study is to provide an overview regarding interests and categories of drugs consultation needed by T2DM patients and to determine the effect of quality of drugs consultation on patients interest to participate in such program. Survey and interviews were conducted with T2DM patients in outpatient clinic, Dr. M. Salamun Air Force Hospital, Bandung during April-June 2013. One hundred patients were recruited for this study. Most of the patients consumed combination of oral antidiabetic and non-antidiabetic medication (71 %) and were given polypharmacy (45 %). The results showed that the information regarding drugs interactions, adverse drugs reaction (ADR), and drugs dosage were among the aspects that should be included in drugs consultation service by pharmacists. The quality of drug information service was associated with increased interest to participate in such program. These aspects should be considered in the implementation of drugs consultation program by pharmacists.
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