Background: Many studies were made the association between the extent of the inflammatory response, increase fibrinogen level and hypercoagulability in rheumatoid arthritis. The current study aims to the investigation and finds the association of the fibrinogen, ESR and CRP levels in Sudanese patients with rheumatoid arthritis. Material and Methods: This is a case-control study, conducted at Modern Medical Center, Khartoum, Sudan, during January 2016. Totally 100 participants were chosen for this study, among them 50 were known Sudanese patients professionally diagnosed with rheumatoid arthritis as case group, and the other 50 participants were normal healthy subjects as control group; their age and gender coordinated with case group. 3 ml of blood was collected in Tri Sodium citrate container, and other 3 ml in plain container. Platelet poor plasma prepared by centrifugation of tri sodium citrate container, and then plasma separated to estimate fibrinogen. Serum was prepared form clotted blood to measure CRP. The ESR was done by Westergren tube from citrated blood in one hour .The data were collected by structured interview and questionnaire, and then analyzed by using a computer program statistical package for social sciences (SPSS) version 20. Results: Significant elevated of the plasma fibrinogen, CRP levels and ESR were observed in subjects with rheumatoid arthritis in comparison with that normal control group with (p value 0.000). Conclusion: This study has shown that rheumatoid arthritis lead to increase level of fibrinogen, ESR and CRP. This abnormality could be contributed to the hypercoagulability phenomenon.