Association of Fibrinogen, Erythrocyte Sedimentation Rate and C-Reactive Protein Levels with Rheumatoid Arthritis

Abstract

Background: Many studies were made the association between the extent of the inflammatory response, increase fibrinogen level and hypercoagulability in rheumatoid arthritis. The current study aims to the investigation and finds the association of the fibrinogen, ESR and CRP levels in Sudanese patients with rheumatoid arthritis. Material and Methods: This is a case-control study, conducted at Modern Medical Center, Khartoum, Sudan, during January 2016. Totally 100 participants were chosen for this study, among them 50 were known Sudanese patients professionally diagnosed with rheumatoid arthritis as case group, and the other 50 participants were normal healthy subjects as control group; their age and gender coordinated with case group. 3 ml of blood was collected in Tri Sodium citrate container, and other 3 ml in plain container. Platelet poor plasma prepared by centrifugation of tri sodium citrate container, and then plasma separated to estimate fibrinogen. Serum was prepared form clotted blood to measure CRP. The ESR was done by Westergren tube from citrated blood in one hour .The data were collected by structured interview and questionnaire, and then analyzed by using a computer program statistical package for social sciences (SPSS) version 20. Results: Significant elevated of the plasma fibrinogen, CRP levels and ESR were observed in subjects with rheumatoid arthritis in comparison with that normal control group with (p value 0.000). Conclusion: This study has shown that rheumatoid arthritis lead to increase level of fibrinogen, ESR and CRP. This abnormality could be contributed to the hypercoagulability phenomenon.

Immunological, Physiological, Andbiochemical Study of Some Patients With Rheumatoid Arthritis in Kirkuk City

“…This study showed significance increase in blood serum These results coincide with the studies of (25,26) ; they found significant increase of blood serumCRPin rheumatoid arthritis patients in comparison with control group.…”

The Fidelity of Rheumatoid Arthritis Multivariate Diagnostic Biomarkers Using Discriminant Analysis and Binary Logistic Regression

“…Fibrinogen is one of the acute phase proteins [ 52 ], meaning elevated fibrinogen levels in plasma should enhance rouleau formation and increase ESR. However, fibrinogen and ESR are elevated in RA [ 53 ], but in vitro experiments suggest that IL-4, which is also elevated in RA, inhibits the production of fibrinogen [ 54 ]. Taken together, although we could not fully explain the inconsistent, weak correlations between the probability of RA prediction based on our algorithms and conventional laboratory markers of RA, such findings do not surprise us given the complexity of the underlying mechanisms.…”