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This study aimed to investigate the antioxidant and protective effect of Eremurus persicus (Jaub & Spach) leaf hydroalcoholic extract (EPE) in preventing gastric ulcers induced by ethanol in rats. Wistar rats weighing 180-220 g were randomly divided into ve groups, included normal group, ethanol consumption group, ranitidine treatment experienced group, the recipient rats prepared by dose of 250 mg/kg plant extract, and the last group recipient the dose of 500 mg/kg plant extract. The gastric ulcer was induced by feeding 1 ml of 96% ethanol to each animal. The gastric ulcer index (UI), pH, oxidative stress parameters, and histopathological changes in all stomachs were measured. Pre-treatment of ethanol-induced rats with the EPE reduced (P<0.05) the ulcer index and gastric juice pH, compared to ethanol intake rats. Additionally, pre-treatment with EPE at a dose-dependent manner alleviated the gastric oxidative stress injury in rats by increasing CAT activity, tissue NO • and GSH levels. EPE also was able to decrease the levels of ROS, MDA, PCO and serum NO • . According to the results, it can be concluded that pre-treatment with EPE prevents the formation of gastric ulcers caused by ethanol, which can be attributed to the antioxidant activity of plant polyphenols compounds.

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