No abstract

BACKGROUNDMast cells have received little attention in leprosy, but evidence linking them with delayed-type hypersensitivity reactions raises the possibility that they may be of some importance in leprosy.

Introduction: Tuberculosis is a leading cause of morbidity and mortality in India which requires early diagnosis for treatment and control of infection. Fine needle aspiration cytology (FNAC) and Ziehl Neelson (ZN) staining of FNA samples have low specicity and sensitivity respectively in tuberculous lymphadenitis due to paucicellular nature of the disease. Fluorescent Microscopy has a well established role in detection of tuberculosis. Recently, WHO has recommended its use in extrapulmonary tuberculosis as an initial diagnostic tool. Material and Methods: This is a prospective study performed in Department of pathology and included 80 patients of suspected symptoms of tuberculous lymphadenitis. Fine needle aspiration was done and the material was sent for Fluorescent Microscopy. The rest of the material was used for preparing H&E stained and Z-N stained smears. Out of the total 80 cases, 47 cases were positive Result: for AFB on ZN staining and 56 cases showed Fluorescent Microscopy positivity, thus proving the important role of Fluorescent Microscopy in diagnosing tuberculous lymphadenitis. This difference was also statistically signicant (p value <0.05). Combined Conclusion: use of FNAC, ZN staining and Fluorescent Microscopy gives maximum diagnostic yield, greatly improving diagnostic value specially in patients with low bacillary load, those are likely to be missed on FNAC & ZN staining by increasing the rate of detection of tuberculous lymphadenitis

Bone marrow examination is an important tool for the diagnosis of various hematological disorders. It involves the use of bone marrow aspiration (BMA) and bone marrow biopsy (BMB). To compare concordance and discordance rate between bone Objectives: marrow aspiration and trephine biopsy ndings in making etiological diagnosis in pancytopenia patients. A cross Material And Methods: sectional prospective study was conducted in department of pathology MAMC, Agroha on 36 cases of pancytopenia to compare the ndings of bone marrow aspiration and bone marrow biopsy. The overall concordance and discordance rate between BMA and BMB wa Results: s 63.8% and 36.2% respectively. Conclusion: It was concluded in our study that BMA and BMB are important, useful complementary diagnostic procedures which gives a higher diagnostic yield when performed simultaneously.

Background: CNS tumors are heterogenous variety of tumors and brain parenchyma is the most common site of CNS tumors, followed by meninges, sellar region and nerves. Meningiomas arise from meningothelial cells of the arachnoid and are attached with the duramater. WHO grading based on the histopathololgical features, alone has limitations in predicting the exact behavior of meningiomas. Hence, the use of immunohistochemical markers like Ki-67 helps in determining the aggressive nature of the tumor and its recurrence potential. To correlate Aim: the signicance of proliferative marker Ki-67 with histological classication and grading of meningiomas cases were taken. Material and Method: A cross-sectional study carried out in the Department of Pathology at Maharaja Agrasen Medical College Agroha, Hisar with sample size of 35 biopsies/excision specimens of meningiomas cases. In the present study, Result: female outnumbered male with female:male ratio of 1.7:1 and mean age of 48 years. Out of 35 cases, 30 cases (85.7%) were of grade I and 5 (14.3%) were of grade II. No case of grade III meningioma was recorded. Mean Ki-67 LI was 6.40±14.21 in grade I and 19.60±12.88 in grade II. So, grade II had signicantly more mean Ki-67 LI compared to grade I and was statistically signicant with p value <0.05. IHC evaluation Conclusion: with Ki-67 LI do add information to the routine histopathological evaluation of meningiomas, and helps in assessing the biological behaviour of meningiomas and in formulating the suitable treatment plan for various grades of meningiomas and follow up of cases as early as possible. So, the use of Ki-67 LI in the histomorphological study of meningiomas is a supplement in determining the histological grade, not a substitute and is of signicance for appropriate management.