using in-depth interview technique. Krippendorff's content analysis method was utilized for data analysis. Results: Eight categories and 26 themes were extracted from the data which illustrated the lived distress of the patients with ostomy. The categories were "do not have any freedom to eat whatever I wish to eat", "uncontrolled defecation", "have to live through tough situation", "keep stoma in suspense", "disgusting ostomy", "can not live with comfort", "easily take a pessimistic view", and "see how the wind blows in daily family life". Conclusion: Ostomates were affected by the distress of having an ostomy in their physical, psychological, social and spiritual life. Individualized and continued nursing education program has to be developed in hospital and community settings in order to improve the quality of life of the ostomates. Key Words: Ostomy, Distress