No abstract

We investigated the relation between hepatoglobin (Hp) polymorphism and plasma lipid levels in 913 Korean subjects. The distribution of Hp phenotypes did not show any significant differences between the healthy controls and the patients with cardiovascular disease. In the control group, however, the subgroup of ≧ 50-year-olds had a significantly higher Hp*l allele frequency than the subgroup < 50 years (p < 0.005). This was not seen in the patient group. Hp phenotypes were associated with levels of high-density lipoprotein cholesterol in the hypertensive group. The results indicate that Hp polymorphism, at least in the Korean population, does not predispose to the occurrence of cardiovascular diseases.

No abstract

Although 14 species of mosquitoes were collected in Che-ju Island, Korea in August and September, 1970-1972, dominant mosquitoes feeding on man around dwelling houses were Culex pipiens pallens and Aedes togoi. Natural infections with infective larvae of Brugia malayi were demonstrated only in Ae. togoi. It is considered from these facts that the main vector of malayan filariasis in Che-ju Island is Ae. togoi. Anopheles sinensis which is known as the vector of malayan filariasis in other areas does not seem to act an important role in the transmission in Che-ju Island, because the desnity is very low owing to the scarcity of suitable breeding places. The period for the larvae of Brugia malayi to mature in Ae. togoi was estimated to be between 6 and 9 days from the results obtained by dissecting the females of the mosquito reared in the laboratory for various days after the collection at houses with microfilarial carriers. This period is much shorter than in the case of Wuchereria bancrofti. The breeding of Ae. togoi was observed mainly in rock pools on the seacoast, and only very rarely in artificial water containers within villages. Generally, adult females of this mosquito were abundantly found at houses near to the seacoast, and the density decreased with the distance from the seacoast. Similar tendency was seen in the distribution of the patients of malayan filariasis. Che-ju Island, Korea, which is 1,820 km2 in area, is situated about 370 km southwest west to Tsushima Islands, Japan. In the center of the Island there is a mountain with an altitude of 1,950 m and the plain area is rather small so that rice fields are not much developed. Human filariasis caused by Brugia malayi is known to distribute densely in the Island, in which mosquitoes were studied in 1970, 1971 and 1972 in relation to malayan filariasis. The results obtained will be reported in this paper, as the second part of studies on malayan filariasis in Cheju Island, Korea.

The hippocampus is a central area of the memory-related neural system. Combined immunohistochemistry against choline acetyl transferase and retrograde transneuronal labelling of the pseudorabies virus were used to identify cholinergic neurons in the central nervous system projecting to the hippocampal formation of the rat. Five to ten microL of Bartha strain of pseudorabies virus were injected into the dentate gyrus, CA1 and CA3 of the hippocampus of 20 Sprague Dawley rats using stereotaxic instrument. Forty eight to 96 hr after the injection, the brains were removed and the tissue sections were processed for double immunofluorescence procedure using polyclonal antibodies against pseudorabies virus or choline acetyl transferase. The double labelled neurons were distributed at several different nuclei and the labelling patterns of three different areas of the hippocampus were similar. These data suggests that the cholinergic innervation to the hippocampus were distributed in a transsynaptic manner throughout the whole brain area.