Background: Psoriasis is a chronic inflammatory disorder with proliferative dermatological and systemic manifestations involving multiple organs. Its etiology and pathogenesis is closely related with genetic and environmental factors. The current study was designed to assess the relationship of age at the diagnosis of psoriasis and its impact on their quality of life. The findings thus obtained might help to take appropriate therapeutic and psychological measures together with patients’ counselling to minimize any adverse consequences. Aim: To determine the age of diagnosis of psoriasis and its impact on the quality of life with age quartiles in psoriasis patients. Setting: This cross sectional study was carried out in Dermatology out patients department (OPD) affiliated with Liaquat University Hospital (LUH), Hyderabad from December 2019 to June 2020. Methodology: Total 141 diagnosed cases of psoriasis vulgaris were included in the study. The final data in the form of DLQI SCORE, PASI SCORE in each quartile of age of all patients was collected and findings were noted down in the predesigned proforma. Results: The average age of the patients included in the study was 37.53±12.12 years. There were 103 (73%) males and 38 females (27%) who consented to be the part of the study. Quality of life among 17 (12.06%) patients had little impact, 42 (29.79%) had moderate effect, 77 (54.61%) patients had severe effect and 5 (3.55%) had extreme effect. There is significant effect with respect to age quartiles at diagnosis of psoriasis (p=0.005). Significant effect on quality of life was observed in 1st and 2nd quartile while moderate effect appeared to impact the patients in 3rd quartile of age. Conclusion: Psoriasis is more than just a skin disorder and has a very large effect on patients’ quality of life with noticeable effects having potential to impact their personalities, daily routine activities and even relationships with people around them. Depending upon the severity of the disorder, it could affect quality of life without any discrimination of age, gender, duration and married life of patients. The more it is on the exposed parts, the more it affects their quality of life. Keywords: Psoriasis, Quality of life, DLQI score, PASI score.

Objective: To determine the mean serum level of C-reactive protein in moderate and severe acne patients visiting to a tertiary care hospital. Setting and Duration Study: This study was conducted at Department of Dermatology, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Pakistan, from November 3, 2020 to May 2, 2021. Materials and Methods: This study was conducted in the Department of dermatology,  Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, from November 3, 2020 to May 2, 2021. An inform consent was also taken prior to the enrolment of patients in the study. The selected participants were referred to the laboratory for hypersensitive-CRP (Hs-CRP) measurement. All the patients of any gender, aged between 16 to 40 years associated with moderate and severe acne duration of more than 3 months were included in this study. Effect modifiers were controlled through stratification of age, gender, duration of acne, and severity of acne (moderate / severe) and these stratified groups were compared by applying independent sample t-test by using P ≤ 0.05 as significant. Results: Mean ± SD of age was 22.7±5.3 years. Mean ± SD of C-reactive protein was 4.15±1.2 (μg/ml). In distribution of gender, out of 56 patients, 30 (53.6%) were male while 26 (46.4%) were female. Out of 56 patients 21 (37.5%) had moderate acne vulgaris while 35 (62.5%) had severe Acne vulgaris. Conclusion: It is to be concluded that mean serum level of C-reactive protein in severe acne patients was high as compared to moderate acne patients. Epidemiological and research data should be expanded by further studies to validate the current findings.