Abstract:The objective of the study was to evaluate the drug-drug interaction studies of levoceterizine with atenolol. Calibration curve studies of working standard solutions of levocetirizine and atenolol (0.01~0.1 mmol) were scanned. Maxima appeared at 231 nm for levocetirizine and 224 nm for atenolol. The calibration curve obeyed Beer Lambert's Law. Lone availabilities of both the drugs were studied in pH 1, pH 4, pH 7.4 and pH 9 at 37 °C on B.P. (British Pharmacopoeia) dissolution apparatus. To study the drug-drug interaction of levocetirizine (5 mg tablet) and atenolol (100 mg tablet), both the drugs were introduced to the dissolution apparatus in simulated gastric juice (pH 1), pH 4, pH 7.4 and pH 9 at 37 °C at zero time and measured the absorbance maxima of both the drugs at the corresponding wavelength. Graphs were plotted for availability percentage (%) of drug versus time at each set of experiment. The availability percentage (%) of levocetirizine in the buffers of pH simulated to gastric pH 4, pH 7.4 and pH 9 in the presence of atenolol was 436.78%, 376.90%, 436.78% and 436.78%, respectively, but the availability of atenolol was increased up to 214.80%, 212.96%, 214.93% and 231.51% in simulated to gastric pH and in the buffers of pH 4, pH 7.4 and pH 9, respectively. On the basis of these studies, it is concluded that levocetirizine forms a charge-complex with atenolol; therefore, co-administration of these drugs should be avoided.

Sixty subjects were selected and were divided into two groups. Group A included 30 patients of end stage renal disease on regular dialysis and group B included 30 normal healthy subjects as control. Absolute values and Hb were done by hematology auto analyzer and serum and red cell folate were done by commercially available kits. Results were analyzed by using Student`s `t` test and level of significance was done. A significant decreased in serum and red cell folate in end stage renal disease patients with regular dialysis as compared to control.

Background: Geriatrics refers to age-related health changes and consequently causes complications in polypharmacy, generalizing prescribing patterns. The study aimed to investigate the pervasiveness of medication inaccuracies along with drug interactions. Methodology: Out of 450 prescriptions only 210 were selected that contained Calcium Channel Blocker (CCB) and other drugs. Drug-drug interactions were articulated by Micromedex 2.0, and the harm score was determined by National Coordinating Council for Medication Error Reporting and Prevention. Results: The outcomes revealed that 645 medication errors were identified and multiple errors were present in a single prescription. The most frequent error was unstated patient's weight (98.6%) proceeds from drug-drug interactions (66.7%). According to the harm score, 36.66% of prescriptions were placed in category D, there was a statistically significant association between the drug-drug interaction and the number of prescribed drugs (p<0.0001). Conclusion: The prime solution is that the physicians should be facilitated withal trainings about drug interactions and prescription writing skills according to WHO guidelines or other recognized standards.

No abstract