T he aim of this commentary is to discuss from a rehabilitation perspective the Cochrane Review "Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery" by Molenaar et al. 1 (https://www.cochranelibrary. com/cdsr/doi/10.1002/14651858.CD013259.pub2/full), published by Cochrane Colorectal Group. This Cochrane Corner is produced in agreement with the American Journal of Physical Medicine and Rehabilitation by Cochrane Rehabilitation with views of the review summary authors in the "implications for practice" section.Background: Colorectal cancer is more common in the older people and is considered the fourth most deadly cancer. However, over the past few decades, its incidence in people younger than 50 yrs is increasing. 2 Colorectal cancers are associated with poor health-related quality of life (HRQoL) due to direct consequences of disease (anemia, fatigue, abdominal pain, change in bowel habits) and adverse effects of treatment. 3 Prognosis of colorectal cancer is guarded except for patients with nonmetastatic disease. 3 Surgical resection of tumor is the cornerstone for treatment. 3 There is evidence that postoperative rehabilitation substantially improves functional outcomes and enhance recovery in these patients. 4 However, data regarding the efficacy of multimodal prehabilitation in improving functional status and HRQoL in patients with nonmetastatic colorectal cancer are limited.Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery (Molenaar CJL, van Rooijen SJ, Fokkenrood HJP, Roumen RMH, Janssen L, Slooter GD, 2022). WHAT IS THE AIM OF THIS COCHRANE REVIEW?The aim of this Cochrane Review was to determine the effects of multimodal prehabilitation programs on functional capacity, postoperative outcomes, and HRQoL in patients with colorectal cancer undergoing surgery.

Long COVID is a term used to describe the persistence of symptoms in people who have had COVID-19 for an extended period. It affects multiple systems including neurological (fatigue, brain fog, attention issues, memory issues), neuromuscular (sarcopenia, myositis, arthritis and myopathy), cardiovascular (myopericarditis, right ventricular dysfunction, vasculitis and aortic, arterial and venous thrombosis) and respiratory (pulmonary fibrosis, pleurisy, pulmonary embolism and pneumonitis). This results in functional impairments which adversely affect the quality of life of patients. The rehabilitation of persons who have experienced long COVID-19, also known as "long haulers," is a relatively new field of study. We have described potential rehabilitation interventions to improve functional capacity and quality of life in patients with long COVID. These rehabilitation interventions include but are not limited to, endurance, flexibility and strength training, pulmonary rehabilitation, task specific exercises to improve Activities of Daily Living (ADL), psychological rehabilitation, medical rehabilitation, pain management and management of dysphagia. Keywords: Long haulers; Chronic COVID; aerobic training; cognitive behavioural therapy; activities of daily living; rehabilitation

An isolated musculocutaneous nerve (MCN) injury is a rare condition that can be easily missed if it presents late. A 28-year-old man reported painless and progressive wasting of the right arm for 6 months. On examination, there was visible wasting of the right biceps brachii muscle along with its slight weakness, depressed biceps jerk, and an impaired pinprick sensation in the lateral antebrachial cutaneous nerve distribution. He described a history of a road traffic accident 14 months beforehand. Based on the history and clinical examination, the differential diagnosis included an isolated MCN injury, upper trunk plexopathy, lateral cord plexopathy, C5/6 radiculopathy, and monomelic amyotrophy involving the C5/6 myotomes on the right side. The results of nerve conduction studies and electromyography were consistent with chronic proximal MCN neuropathy (right). In cases of arm wasting without pain or numbness, MCN injury should be included in the differential diagnosis, even in the presence of good power of the elbow flexors. The importance of detailed history-taking and clinical correlation cannot be over-emphasized in such cases.

Antimuscarinics are first-line medication for management of overactive bladder with solifenacin being commonly prescribed. Angioedema is the swelling of mucosa and submucosal tissue. There are no published case reports of drug-induced angioedema involving solifenacin. We report a case of a 41-year-old man with spinal cord injury who presented with oedema of face, lips, tongue and associated pruritic urticaria after taking 5 mg of solifenacin. All other possible causes including food allergy, insect bite, hereditary angioedema, use of NSAIDs, ACE inhibitors and antibiotics were ruled out. The temporal association between solifenacin and angioedema and complete resolution of symptoms after discontinuing the drug suggest that solifenacin was the most probable cause of angioedema in our patient.

Objective: To describe prosthetic/cosmetic rehabilitation of partial hand amputations. Study Design: Case series. Place and Duration of Study: Out Patient Department (OPD) of the Rehabilitation Department Combined Military Hospital Multan from Jul to May 2020. Methodology: Patients with partial hand amputations, due to any cause, reporting to OPD of Rehabilitation Department in CMH Multan were included. Demographic data (age, gender, education), cause, type and duration of injury and cosmetic intervention were documented. Results: A total of 10 patients were recruited. All the participants were males. The mean age of the patients was 34.1 ± 2.8 years. The average duration of amputation was 5.2 ± 1.7 years. The most common cause of amputation was blast injury (n=3), followed by injury with heavy machinery (n=2), firearm injury (n=2), fall from the train (n=1), electric injury by high tension wire (n=1), and frostbite (n=1). The type of amputation included: left transmetacarpal with thumb sparing (n=3), ray amputation of the right index finger (n=3), right transmetacarpal with thumb sparing (n=1), ray amputation of the right middle finger (n=1), amputation left partial thumb and index finger (n=1), the right fourth and fifth finger amputation (n=1). All the patients could carry out activities of daily living even without a prosthesis. Ottobock silicon finger fillers with cosmetic sleeves were provided to all the patients. Conclusion: Aesthetically acceptable silicon finger fillers are the mainstay of rehabilitation of hand amputations in lower-middle-income countries with poor access to rehabilitation.