The aim study to search the role of selenium in Biochemical parameters of  role of selenium in reducing the side effect codeine in the level of certain hormones The study included 30 female domestic rabbits were divided into six groups of 5 animals per group show by studying the presence of high-rise moral (P ≤0.01) in the rate of the hormone AMH levels in serum in the third-sixth group compared to the first group. Absence of significant difference in the rate of the hormone AMH levels in the second group and the fourth-fifth group compared to the first group and the occurrence of high-low morale (P≤0.01) in rate progesterone levels in the blood serum in Group second and Group third and Group fourth fifth and sixth group and the group compared to the first group. And the presence of high moral decline (P≤0.01) in the rate of estrogen levels in the blood serum in Group second and Group third and Group fourth and fifth and sixth group and the group compared to the first group. And the occurrence of highly significant in the rate of LH hormone levels drop in blood serum in Group fourth compared to the first group. and the absence of significant differences in the rate of LH hormone levels in the blood serum in the first group and the fifth group and the third and sixth group compared to the first group. And a decline highly significant at the level of probability (P≤0.01) in the rate of FSH levels in serum in  third Group  and fifth Group and sixth group compared to the first group. The results showed no significant differences in the rate of FSH levels in serum in the scond group compared to the first group.

This study was conducted to investigate the effect of watery extract of Cumin plant (200 mg/kg B.W.) on some physiological and histological parameters of the male reproductive system in white albino rats exposed to oxidative stress by Hydrogen peroxide (H2O2 0.5%). Thirty adult male rats weighting about (200-250 g) and 10-12 weeks age were used in the present study and divided into (5) groups, 6 rats per group, group1: serve as a control group and given normal diet with drinking water, group2: Administrated H2O2 0.5% with drinking water, group3: Given Cumin extract (200 mg/kg B.W.) through oral tubular feeding + H2O2 (0.5%), group4: Given Cumin extract (200 mg/kg B.W.) alone and group5: Administrated Vitamin E 500 (mg/kg B.W.) with H2O2 0.5%, the experiment were continued 30 days for all groups. The results of the current study showed that treatment with H2O2 resulted significant increase (P<0.05) in malondialdehyde, significant decrease (P <0.05) in glutathione and significant decrease (P<0.05) in serum testosterone compared with control group, While the treatment with H2O2 plus the water extract of Cumin seeds (200 mg/kg B.W.) showed a significant decrease (P<0.05) in malondialdehyde, a significant increase in glutathione and a significant increase in testosterone in the serum compared to the H2O2 group. As for ectopic tissue, H2O2 has resulted in satisfactory tissue changes, while water extract (200 mg/kg) with H2O2 resulted in little improvement of the testes tissue. The water extract of Cumin plant acts as an antioxidant through its important role in curbing the harmful effects of some types of free radicals within the body and thus repair the damage in most of the physiological and histological changes and functions of the male reproductive system of rats with exposure to oxidative. Histological section of the testes in the rats treated with vitamin E and H2O2 observed repair of the cells lining the seminiferous tubules with the continuation of the formation of sperm, on the other hand the results showed that giving the Cumin for a long periods lead to reduce the level of hormone testosterone

The aim of study to determine out the role of CoQ10 in reducing the side effects from the use of Tramadol on the level of Interlukin IL-6, IL-10 and PGF2α the study included 30 endemic female rabbits, where each group included  5 animals. The results showed increase with a highly significant with (P≤0.01) in the concentration of IL-10 in sera of treated group with tramadol (initial dose) and group treated tramadol (double dose) group treated tramadol (initial dose + CoQ10) and group treated  with tramadol (double dose + CoQ10) compare with control. The results showed no significant differences in the concentration of IL-10 in sera of treated group with Co Q10 compare with control. The results revealed  high significant increase  (P≤0.01) in the concentration of IL-6 in the sera of the treated group with  tramadol (double dose) group treated with  tramadol (initial dose + COQ10) as compared with the control and the results showed the presence of high significant decrease (P≤0.01) in the concentration of IL-6 in the sera of the group treated with tramadol (initial dose) and treated with group tramadol (double dose + COQ10) compare with control. the results showed there were no significant differences in the concentration of IL-6 in serum of group treated with CoQ10 as compare with control. Results indicated occurrence of high significant increase (P≤0.01) in a concentration of PGF 2α in serum of the group  treated with tramadol (initial dose) and group treated with tramadol (double dose)and group treated with tramadol (initial dose + CoQ10) and group treated with tramadol (double dose +CoQ10) compare with control. The results showed presence of a highly significant decrease (P≤0.01) in the concentration of P G F 2α in sera of group treated  with  CoQ10 as compare with control.