The aim of the study was to determine the etiopathogenesis of reproductive dysfunction in highly productive cows. Studies were conducted on cows of black-motley breed, aged 3–5 lactations, with a live weight of 480–520 kg. Cows were divided into two groups. The first group included 20 cows effective inseminated after the first insemination. The second group included 17 cows that did not fertilize after the first insemination. Blood samples (n = 253) were taken from 4–7; 14–17; 24–34; 35–50; 88–95; 195–210 days of pregnancy; during the beginning of dry period (DP); 1–4 days before calving and on the first day after calving. The content of total serum lipids in pregnant animals was 15.8% higher compared to unfertilized animals. In non-pregnant cows, a decrease in free cholesterol (by 28.65%), especially in its ether-bound fraction (14.91%), indicates a lower synthetic function of the liver, which is confirmed by the low serum levels of vitamins A and E (a difference of 11.3 and 23.65%). The DP was characterized by a significant increase in the products of lipid peroxidation - malondialdehyde by 12–17%, diene and triene conjugates - by 10–15 and 8–15%, respectively, and 1–4 days before calving in cows, which subsequently had a pathological calving, in particular - retention of placenta (5 cows), were characterized by an increased content in the blood plasma of lipid peroxidation products. Thus, the difference in the number of dienes, trienes, and malondialdehyde products was 14.0, 12.0, and 23.5%, compared with animals without obstetric pathology. On the first day after calving, this difference increased even more. Cows with retention of placenta had a significantly higher level of lipid peroxidation products and were characterized by a predominance of oxidized products over the antiradical thiol disulfide and ascorbate systems restored in the antioxidant balance.

The purpose of researches is rising of efficiency of prophylaxis of cows patrimonial and puerperal pathologies. The current of cows labors and the puerperal period when using homeopathic medicine is studied Tsimaktin. It is estab-lished that drug Tsimaktin use reduces duration of cows current of labors in comparison with control by 1.87 hours. An involution of body and horns of experienced group uterus animals came to the end for 11.35 days earlier. Dis-turbances of involutional processes of control group cows reproductive organs to whom use didn't administer the drug 20% more Tsimaktin than at animals of experienced group. It is taped that drug Tsimaktin raises the morpho-functional status of cows organism that is confirmed by hematological and biochemical indicators of blood. The hemoglobin content, erythrocytes in control group cows blood after calvin was reliable less, than indicators of ani-mals of experienced group respectively on 15.09 g/l and on 1.94 1012 l. The indicator of the general protein in blood serum of experienced group cows is 2.69 g/l more than at cows of control group. The quantity of β-globulins after the delivery are more for cows of control group in comparison with experienced for 7,33% that indicates existence of inflammatory process in an organism of animals. Control group cows for 4-5 day the atsidotichesk state was after the delivery observed what the smaller indicator of an alkaline reserve on 3.38 ob%CO2 testifies to. Use of homeopathic medicine Tsimaktin in 25-30 days prior to labors allowed to raise cows fecundity and to reduce the number of days of sterility. Use of this drug is ecologically safe and allows to use milk without restrictions. On the basis of the conducted researches drug Tsimaktin can be recommended for prophylaxis of puerperal complications at cows.

Following an analysis of factors which hinder the development of the regional tourism sector, for the purpose of the regional travel industry development the article justifies the need for development of a new product of the Crimean tourism industry – food tourism. The article explores the potential of the concept of food tourism promotion and development based on prospects available for the different parties concerned. To identify the parties concerned and their motives, the article has addressed conceptual issues relating to a connection between food tourism and tourism sector development; potential of food tourism as an instrument of region development; strategy to be evolved to encourage development of food tourism. It has been established that the parties interested in the origin and development of food tourism may be grouped into four separate categories depending on geographic scope of their operations, business profile and value of their interests: 1) “state regulatory authorities” – regional and municipal state authorities; 2) “food intermediaries” that comprise a wide range of the concerned market players involved in tourism and related sectors; 3) “farmers (producers) and restaurant keepers” involved in provision of food services or production, “public concerned” – volunteers involved in surveys, the findings of which may be used for the development of strategies. It has been found out that the development of food tourism in the Republic of Crimea requires consolidation of efforts, knowledge and capabilities of all the parties interested in the diversification of tourism product, extension of time frames of a high tourist season and increase in marketability of the regional tourism product, in particular, and tourism sector, in general.

The aim of the study is improving the efficiency of cows acute postpartum endometritis treatment by use of the drug Metrolek-O. For the treatment of cows acute postpartum endometritis was used the drug Metrolek-O in the dose of 40, 50 and 60 ml with an interval of 48 hours, intrauterus. For the study of blood counts during the cows treatment of the studied groups, blood was taken before and after clinical diagnosis of healing. Blood was taken from 5 cows from each group of IP-using system «Monojet» from tail vein. It was found that sick animals reduced content in the blood: hemoglobin – 22.80 g/l; erythrocytes – х1012 of 1.05 g/l; segment reflexology point pressure-nuclear neutrophils – was 4.02%; globulins – to 10.97% at simultaneous increase in quantity of leukocytes by 2,94х109 g/l and albumin – to 10.97%. When we use dose of the drug Metrolek-O – 50 ml morphological and biochemical blood parameters had large indicators that correspond to background. Drug Metrolek-O in the dose of 50 ml of the more effective as it provides normalization of the gradient of blood and recovery of animals by anti-inflammatory, antimicrobial, constant and regenerating properties, and increasing the dose to 60 ml ineffective because of the allergic properties of the drug, as evidenced by the increase of eozinophils 1.89%.