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CORTISONE IN NON-RHEUMATIC CONDITIONS BJoRNH treated by adrenalectomy and cortisone: in neither did the results obtained appear to justify the risks involved. 17-ketosteroid excretion was controlled in two pseudohermaphrodites by the use of cortisone. The beneficial effect of cortisone and A.C.T.H. in asthma has been confirmed. The use of A.C.T.H. by intravenous drip and of cortisone by inhalation usually brought prompt improvement and was an important economy in prescribing. In two patients with nephrosis a considerable diuresis attended treatment, and in one of them the remission obtained has lasted more than a year. There is no evidence that A.C.T.H. influences portal hypertension accompanying cirrhosis, though apparent clinical benefit occurred in one patient. We are grateful to the physicians and surgeons of the General Infirmary at Leeds and the Hospital Cortisone Committee, who have allowed us to publish details of patients under their care. We are indebted to the Medical Research Council for the cortisone used in the treatment of exophthalmic ophthalmoplegia and to Armour Laboratories for a supply of acthar gel.

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