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Proton therapy is a precise forms of radiation therapy that makes use of high energy proton compared to the conventional, more commonly used and less precise x-ray and electron beams. On the other hand, to fully exploit the proton therapy advantages, very accurate quality controls of the treatments are required. These are mainly related to the dose calculations and treatment planning. Actually dose calculations are routinely performed on the basis of X-Ray computed tomography while a big improvement could be obtained with the direct use of protons as the imaging system.In this work we report the results of Monte Carlo simulations for the study of an imaging system based on the use of high energy protons: the proton Computed Tomography (pCT). The main limitation of the pCT and the current adopted technical solutions, based on the use of the Most Likely Path (MLP) approximation are illustrated. Simulation results are compared with experimental data obtained with a first prototype of pCT system tested with 200 MeV proton beams available at the Loma Linda University Medical Center (LLUMC) (CA).

We report the results of a beam experiment to develop proton Computed Tomography (pCT). The setup consists of telescopes of silicon strip detectors at the entrance and exit of a phantom to predict the path of the proton within the phantom and of a crystal calorimeter to measure the proton energy loss with high precision. The energy loss permits calculating the integrated proton stopping power along each proton path from which the electron density distribution can be reconstructed. We describe the 2D-image reconstruction of a lowcontrast phantom, derive the relationship between contrast, pixel size, and dose, and study the spatial resolution achievable with this setup .