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The published data on the preparation and the The published data on the preparation and the dispersion-structural properties of nano-sized TiO dispersion-structural properties of nano-sized TiO 2 2 are are considered. Attention is focused on its sol ± gel synthesis considered. Attention is focused on its sol ± gel synthesis from different precursors. The possibilities for the purpose-from different precursors. The possibilities for the purposeful control and stabilization of properties of TiO ful control and stabilization of properties of TiO 2 2 nano-nanopowders and sols are analyzed. Information on powders and sols are analyzed. Information on physicochemical methods used in studies of the particle physicochemical methods used in studies of the particle size and the phase composition of nanodisperse TiO size and the phase composition of nanodisperse TiO 2 2 is is presented. The prospects of using nano-sized TiO presented. The prospects of using nano-sized TiO 2 2 in in medicine and nanobiotechnology are considered. The bib-medicine and nanobiotechnology are considered. The bibliography includes 95 references liography includes 95 references. . Synthesis and stabilization of nano-sized titanium dioxideZ R Ismagilov, L T Tsykoza, N V Shikina, V F Zarytova, V V Zinoviev (deceased), S N Zagrebelnyi

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The use of various nanoparticles is a promising way to solve the current problem of drug delivery in medicine and biology. Nanocomposites consisting of titanium dioxide and oligonucleotides noncovalently attached to nanoparticles through the polylysine linker (TiO2 x PL-DNA) have been designed to deliver of DNA fragments into cells. Three forms of TiO2 nanoparticles (amorphous, anatase, and brookite) were used for construction of nanocomposites. The size, morphology, and chemical composition of TiO2 nanoparticles and TiO2 x PL-DNA nanocomposites were characterized. DNA fragments in the proposed nanocomposites were shown to retain their ability to form complementary complexes. TiO2 x PL-DNA nanocomposites independently on the form of nanoparticles were shown by confocal microscopy to penetrate into HeLa cells without any transfection agents and physical impact. The presented type of nanocomposites can be applied in the thriving technology of drug delivery to achieve high therapeutic and biological efficacy.