SUMMARYA hospital-based case-control diarrhoea survey was conducted in Cairo, Egypt to determine the age-specific frequency of campylobacter infection among diarrhoeic and non-diarrhoeic children aged new born to 5 years. Campylobacter was the most common bacterial enteropathogen isolated from diarrhoeic stools. The overall prevalence of campylobacter isolations was 25 9 % from stools of 143 diarrhoeic children compared to 152 % of 132 non-diarrhoeic control children (P = 0 028) during the 4-month period of study. Children less than 1 year of age were at greatest risk of campylobacter infection with 32-6 % of diarrhoeic patients culture positive, compared to 14-3 % of controls. Asymptomatic shedding in controls was positively associated with a recent diarrhoeal episode (P = 0 019) and may be an important source of new infections.

Milk samples were collected from 35 mothers delivering preterm infants and from 35 mothers delivering term infants at 3 time intervals over the first 3 weeks of lactation. The samples were collected by manual expression from both breasts into polyethylene containers and were frozen at -20 degrees C and stored for analysis. The protein content of preterm milks during the first and second weeks is higher than that of term milk (P less than 0.05). The fat and lactose contents during the first week are slightly more in term milk than in preterm milk. During the third week the fat content of preterm milk is higher but its lactose content was lower. All these differences are not significant. These results are discussed.

s235 management with continued utilization of either drug. Sensitivity analysis was conducted using one-way probabilistic analyses with 10% variation in all probabilities and costs. Results: Total pharmaceutical costs accrued after 3 years among patients treated with tobramycin was estimated at $114,400 compared to azithromycin at $62,400. Life expectancy was 0.29 years lower among patients taking tobramycin. Azithromycin was the dominant strategy compared to tobramycin in the base case. Sensitivity analyses indicated pharmaceutical costs for azithromycin were most influential on the ICER. ConClusions: Tobramycin was not cost-effective due to higher cost and reduced capacity to prolong life years without discontinuation of medication in the management of severe exacerbations, compared to azithromycin. This study does not preclude clinical intervention via implementation of both medications in treatment pathways. Further research is needed to determine health economics and outcomes among patients treated with azithromycin and tobramycin as adjunct therapy in management of severe exacerbations. PRS32 CoSt-MiniMization analySiS of adding a new Single inhaleR tRiPle theRaPy (Sitt) foR the tReatMent of PatientS with ChRoniC obStRuCtive PulMonaRy diSeaSe (CoPd) in the uK

The study of Histocompatibility Locus Antigen (HLA) frequencies in 48 cases with congenital heart disease (CHD) in children in Cairo showed high incidence of A10. Cases with atrial septal defect have shown a significant association with A3 besides A10. There is also a significant association between B12-45 and right loop anomalies (Fallot's and pulmonary stenosis) together with A10. On the other hand, children with rheumatic heart disease have shown strong positive association with HLA group B8 and negative association with A28.

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