s235 management with continued utilization of either drug. Sensitivity analysis was conducted using one-way probabilistic analyses with 10% variation in all probabilities and costs. Results: Total pharmaceutical costs accrued after 3 years among patients treated with tobramycin was estimated at $114,400 compared to azithromycin at $62,400. Life expectancy was 0.29 years lower among patients taking tobramycin. Azithromycin was the dominant strategy compared to tobramycin in the base case. Sensitivity analyses indicated pharmaceutical costs for azithromycin were most influential on the ICER. ConClusions: Tobramycin was not cost-effective due to higher cost and reduced capacity to prolong life years without discontinuation of medication in the management of severe exacerbations, compared to azithromycin. This study does not preclude clinical intervention via implementation of both medications in treatment pathways. Further research is needed to determine health economics and outcomes among patients treated with azithromycin and tobramycin as adjunct therapy in management of severe exacerbations. PRS32 CoSt-MiniMization analySiS of adding a new Single inhaleR tRiPle theRaPy (Sitt) foR the tReatMent of PatientS with ChRoniC obStRuCtive PulMonaRy diSeaSe (CoPd) in the uK

No abstract

No abstract

No abstract

0 1 7 ) A 3 9 9 -A 8 1 1 A641 factor was medicine use affecting 6 (2.9%). Furthermore, only 46 (22%) patients used precautionary measures and confirmed its effectiveness in preventing the asthmatic attack when they were exposed to the risk factors. Out of 192 who were prescribed with the inhaler only 59.4% patient can use inhaler effectively and 88.5% keep it with them while traveling to prevent the worsening of asthmatic attack. ConClusions: Asthma is not a fatal disease but can prove fatal by negligence. Avoidance of risk factor is the primary care in asthma. The use of the precautionary measures was proved to be of great importance in preventing asthma. The use of inhalers was also prescribed but many patients were unable to use them correctly leading to their therapeutic failure.