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Naphthoquinones are compounds widely distributed in the environment, both as natural products and as pharmaceutical agents. They have been the subject of much research due to their pharmacological activities. In this study, methanol extract of henna and a series of synthesized structural analogue of lawsone have been assessed for their antimicrobial activities. Methanol extract of henna and eight naphthoquinones derivatives were tested as potential antimicrobial agents against twelve bacteria and three Candida species using the agar disc diffusion and broth microdilution methods according to guidelines recommended by the Clinical and Laboratory Standards Institute. Besides 2b and 3b, methanol extract and all the synthesized compounds 1a, 2a, 1b and 1c, 2c and 3c showed weakto-strong activity against at least one tested strain. However, the compounds 1c and 1b were found to have the most effective activity against pathogenic bacteria and displayed an activity 8 to 64 fold higher than that othe structural analogue, lawsone. Their MICs ranged from 8-64 µg ml -1. Henna extract was found to have an interesting activity. Our results indicate an effective in vitro activity of 1,4-naphthoquinone derivatives and suggest the benefits of further studies for its application in antibiotherapy.

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Purpose The use of phytotherapy is common worldwide and especially in Algeria. This practice was transmitted orally and ritually to treat chronic diseases. Safe extracts of edible plants can provide a resource of structurally diverse molecules that can effectively interfere with multifactorial diseases, such as diabetes mellitus. The objective of this work is to study the biochemical parameters of diabetic populations who consume medicinal plants. Methods This study involved 100 T2D subjects, recruited over a five-month period via a questionnaire containing anthropometric information: sex, age, age of diabetes, type of diabetes, plants consumed. Recruited patients were recalled for further examination of the biochemical record (fasting glucose, glycated hemoglobin, total cholesterol, triglycerides, creatinine, ASL and ASP). Results We found that diabetic patient associated with prescribed medical treatment uses the medicinal plants. This use is strongly predominant by women in both populations with 76% of them using herbal medicine. 58% of diabetics under herbal medicine had slightly unbalanced diabetes with HbA1c > 7. The difference between the total cholesterol, ASL and ASP parameters of the two populations was not significant. The study of correlation showed that the consumption of plant had an effect on the type of correlation between biochemical parameters of diabetic patients. Conclusions The consumption of medicinal plants did not affect the values of the measured biochemical parameters, while the correlation between these parameters can be modified.

Les conservateurs sont des produits chimiques ajoutés aux produits cosmétiques pour les protéger contre toutes contaminations microbiennes qui se produisent lors de la fabrication ou pendant leurs usages par les consommateurs. Dans notre travail nous avons examiné l’efficacité de conservation des extraits des racines de Fredolia aretioides et d’Echium vulgare dans trois types de formulations de shampoing. L’incorporation des extraits des flavonoïdes 1-butanol ou l’acétate d’éthyle des racines d’Echium vulgare à une concentration finale de 1 % dans nos formulations de shampoing a induit une réduction des inocula. Il est important de noter que les shampoings ainsi préparés sont conservés contre la prolifération des bactéries et des levures et répondent par conséquent, au critère A de la Pharmacopée européenne. Au contraire, comme pour les bactéries et les levures, le shampoing sans conservateur était un bon substrat de croissance. De nombreuses publications ont rapporté l’effet synergique de l’EDTA avec des conservateurs synthétiques ou naturels. Les résultats que nous avons obtenus ont montré que cet agent chélateur utilisé à une concentration finale de 1 %, améliore nettement le pouvoir conservateur des deux extraits testés. La réduction des inocula est estimée à 103 au 7e jour du test sans aucune augmentation au 14e et 28e jours pour les bactéries et à 102 au 14e jour du test sans aucune augmentation au 28e jour pour les levures.