Obesity is a major health hazard not only for developed countries but also for Bangladesh and it is an established risk factor of breast cancer. In our country there is a scarcity of studies on the associations of BMI and different features of breast tumour. This study was aimed to evaluate the associations of BMI with molecular sub-types, clinical and pathological characteristics of breast cancer in Bangladeshi women. This cross sectional descriptive type of observational study was conducted in National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka from September, 2019 to August, 2020. A total of 90 patients with breast cancer were selected purposively according to inclusion and exclusion criteria. An informed consent was sought from the patient to take part is this study. Detail history taking thorough physical examination was done along with relevant investigations. Data were collected by semi structured questionnaire and analysis was done with the help of Statistical Package for Social Science (SPSS), version 21.0. Mean age of the respondents was 41.17 years with a standard deviation of ±8.79 and a range of 24-65 years. Of all, ninety percent patients were housewives and 52.2% belonged to upper middle socio-economic class. About 66.7% patients were pre-menopausal and 33.3% were post-menopausal. The mean BMI of respondents was 25.89(±4.67) kg/m2 and among them 51.1% were obese, 23.3% were overweight and 20.0% had normal weight. No association between BMI and vii molecular subtypes of breast cancer were noted (p>0.05). No association between BMI and hormone receptor status of breast cancer was found. Association with tumor size, axillary lymph nodes, tumor grade and lymphovascular space invasion were also not significant (p>0.05). No association between BMI and molecular subtypes, clinical and pathological features of breast cancer were noted both in pre and post-menopausal groups. This study found no association between BMI and different features of tumor, which could be attributed to small sample size, absence of control and a single centered study. However, further extensive study is recommended.

Background: Lung cancers are increasing not only in men but also in women but there is a few clinical and epidemiological data from developing countries. Female lung cancer is different from that in males. These differences impact on the clinical presentation, histology, and outcomes. Bangladeshi women are less used to tobacco or alcohol use than western countries. But females of Bangladesh now a days presenting with lung cancer is more than past. Methods:The study was an observational study. All histologically confirmed cancer female patients in National Institute of Cancer Research and Hospital and Shaheed Suhrawardy Medical College hospital from Jan.2010 to Dec.2019(10Years) were included. Clinical information and demographic profiles were recorded from departmental documents and retrospectively studied. abstracts Annals of Oncology Volume 31 -Issue S4 -2020 S801

Background: Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD) are LPDs occurring in the use of immunosuppressive agents other than organ transplantations. It is supposed that disease origin might be various such as used medicines, aging, immune abnormality of collagen disease, chronic inflammation, but details are still unclear. We retrospectively analyzed the relationships between clinicopathological features of OIIA-LPD patients and prognosis in our institute.Methods: Twenty-nine OIIA-LPD patients who have visited our department from April 2011 to July 2020 are analyzed. All patients discontinued immunosuppressants at the diagnosis. Patients are consisted by 9 males and 20 females, aged 24-83 y.o. (median 67 y.o.), histologically 12 diffuse large B-cell lymphoma, 6 classical Hodgkin lymphoma, 4 polymorphic PTLD, etc., 27 rheumatoid arthritis and 2 systemic lupus erythematosus in background diseases. Firstly, the effect of clinical features on overall survival was estimated by univariate and multivariate analysis in all patients. Secondary we studied which factors determined the need for any therapies by Fisher's exact test.Results: Poor performance status, B symptoms, advanced clinical stage, elevated CRP, higher sIL-2R were significantly worsened the prognosis in univariate analysis but only B symptoms, elevated CRP, higher sIL-2R were independent prognostic factor in multivariate analysis. Seven out of 29 patients have experienced a regression of OIIA-LPD by withdrawal of immunosuppressants without cytotoxic therapy and CRP was only factors which differed statistically between treated and untreated groups.Conclusion: B symptoms, CRP and sIL2R were correlated with the prognosis of OIIA-LPD patients in our study. But this study is a single-center, retrospective and small number analysis, so that this result was very limited. Multicenter and prospective studies are warranted in the future.

Background: Testicular Cancer (TC) is of interest and importance because its incidence has been increasing in most countries over the past four decades. The purpose of this study is to determine the frequency of patients with common histopathology, most common stage during presentation, biochemical and radiological findings, common levels of tumour markers. Methods: This cross-sectional study was carried out in the Department of Medical Oncology of National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka, Bangladesh from July 2015 to June 2016. A total number of 52 patients were taken as study participants who are admitted as newly diagnosed at the NICRH. Data collection: tumour markers, USG of whole abdomen and chest X-ray were performed to all the patients for determination of the staging of the tumour. Results: The present study found the majority of the patients were found in stage III disease. Patients with Cryptorchidism needed to be educated regarding its early management to reduce the incidence of testicular tumour among them. It was observed that young people could be adequately knowledgeable and optimal awareness could be developed regarding early symptoms of the disease, then they may be found in earlier stage of their disease, which is curable with modern management method. Targeting to alter the cancer patients’ presentation by rising consciousness about TC, prognosis can be largely improved in future. Conclusion: This study was conducted to find out the features which were unknown in perspective of Bangladesh, so that burden of TC can be reduced, and prognosis can be further improved of this potentially curable disease. JOPSOM 2021; 40(1): 26-33