Rift valley fever virus (RVFV) causes severe disease, abortion and deaths in domestic animals (especially) p). At day 28 post injection of the animal, blood was collected for each group then after at sacrifice the liver enzymes (SGPT&SGOT),cellular changes were evaluated using cytokines expression (IFN-γ & IL-5) the exposed and non exposed ELF were studied survival rate and histopathology were demonstrated. The results: In vitro the data highly significant growth enhancement & inhibition respectively occurred in RVFV injected