Schizophrenia is a serious mental illness, and its pharmacological treatment consists in the administration of antipsychotics, such as haloperidol. However, treatment with haloperidol often causes extrapyramidal motor disorders such as tardive dyskinesia (TD). TD is a movement disorder characterized by involuntary movements, which can be studied in animals. So far, there is no effective treatment for TD and alternatives have been sought. Thus, the objective was to evaluate the possible protective effect of iso avones against the induction of involuntary movements induced by haloperidol in an animal model. Male Wistars rats were treated with haloperidol (1 mg/ kg/day) and/or iso avones (80 mg/kg) for 28 days. Rats were submitted to behavioral evaluation to quantify vacuous chewing movements (VCM) and the locomotor activity. In addition, the levels of pro-in ammatory cytokines were measured in the striatum. Haloperidol treatment reduced the locomotor activity and increased the number of VCM in rats. Co-treatment with iso avones was able to reverse hypolocomotion and reduce the number of VCM to the levels of the control group. Besides, haloperidol caused signi cant increase in the proin ammatory cytokines (interleukin-1β:IL-1β, tumor necrosis factor-α:TNF-a and IL-6 and the cotreatment with iso avones was able to reduce the levels of IL-1β and TNF-α, but not IL-6. It is believed that the bene cial effect found with this treatment is related to their anti-in ammatory potential and also to the action on estrogen receptors (based on ndings in the scienti c literature). Finally, further studies are needed to elucidate the mechanisms of iso avones in reducing motor disorders induced by antipsychotic.

No abstract

Schizophrenia is a serious mental illness, and its pharmacological treatment consists in the administration of antipsychotics, such as haloperidol. However, treatment with haloperidol often causes extrapyramidal motor disorders such as tardive dyskinesia (TD). TD is a movement disorder characterized by involuntary movements, which can be studied in animals. So far, there is no effective treatment for TD and alternatives have been sought. Thus, the objective was to evaluate the possible protective effect of isoflavones against the induction of involuntary movements induced by haloperidol in an animal model. Male Wistars rats were treated with haloperidol (1 mg/ kg/day) and/or isoflavones (80 mg/kg) for 28 days. Rats were submitted to behavioral evaluation to quantify vacuous chewing movements (VCM) and the locomotor activity. In addition, the levels of pro-inflammatory cytokines were measured in the striatum. Haloperidol treatment reduced the locomotor activity and increased the number of VCM in rats. Co-treatment with isoflavones was able to reverse hypolocomotion and reduce the number of VCM to the levels of the control group. Besides, haloperidol caused significant increase in the proinflammatory cytokines (interleukin-1β:IL-1β, tumor necrosis factor-α:TNF-a and IL-6 and the co-treatment with isoflavones was able to reduce the levels of IL-1β and TNF-α, but not IL-6. It is believed that the beneficial effect found with this treatment is related to their anti-inflammatory potential and also to the action on estrogen receptors (based on findings in the scientific literature). Finally, further studies are needed to elucidate the mechanisms of isoflavones in reducing motor disorders induced by antipsychotic.

No abstract

<p>O câncer de mama é uma doença estigmatizada que amedronta as mulheres.  A cirurgia de câncer de mama está ligada a alterações, sequelas e complicações em até 70% das mulheres acometidas, afetando sua qualidade de vida, apresentando após a cirurgia dificuldades em realizar suas atividades de vida diária. Na tentativa de minimizar os agravos físicos, psicológicos e sociais pós tratamento do câncer existem várias práticas complementares e auxiliares ao tratamento do câncer, dentre essas enfatizamos a prática da atividade física que repercute em benefícios diretos, aumentando a capacidade funcional. Este estudo visou abordar a importância do exercício físico em pacientes com câncer de mama que realizaram mastectomia e demonstrar seus benefícios. Realizou-se revisão de literatura através de bases de dados eletrônicas Lilacs, PEDro, Scielo, Bireme e PubMed. Vários estudos comprovam a importância do exercício para a melhora da capacidade funcional e qualidade de vida e salientam que para que apresentem o efeito desejado deve ser realizado de forma regular e constante e com acompanhamento profissional. Alguns autores citam fatores que dificultam a realização dos exercícios para estas pacientes, como a falta de tempo, efeitos colaterais do tratamento, desanimo, entre outros. Essa revisão concluiu que os exercícios físicos quando realizados de maneira correta e acompanhados de um profissional conferiram efeitos positivos aos pacientes abordados, mas, no entanto, ainda não fazem parte da rotina de muitos pacientes, justificando a necessidade de divulgação e maiores estudos sobre o tema.</p>