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In the course of our research we have developed a technology for fabricating an osteoplastic material from natural bone tissue. The obtained preparation in the form of gel contains hydroxyapatite, calcium triphosphate compounds and stimulators for regeneration. The proposed experimental material produces a stimulating effect on the growth of animal cell types; it enables to produce bioactive materials with increased biocompatibility. Application of the experimental gel facilitates the process of bone-tissue regeneration in the laboratory animals, which, in its turn, confirms the optimal composition of the material. We have established that during the integration of our osteoinductive material the defect zone is completely replaced by the bone tissue.

In this work, the thermally stimulated spectroscopy methods are applied to PET films exposed to UV rays for the analysis of electrically active defects parameters in these materials, such as activation energy (E a ) and relaxation time, or frequency factor (ω). To obtain these parameters the methods of thermally stimulated currents and thermally stimulated currents thermal sampling were used. To determine the relaxation parameters using the methods of thermally stimulated currents, various mathematical methods of data processing were used. The Eyring equation and the compensation law were found to be the most correct for PET films. The value of the activation energy determined with their help for the PET exposed to UV rays turned out to be 1.07 eV, and the value of effective frequency factor ω = 1/τ 0 = 5 × 10 10 с −1 .

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In the course of this study we established that the laboratory sample in granulated form developed by us has a stimulating effect on the growth and proliferation of osteoblasts. Analysis of the data (CT, MRI) of the biological material obtained from the animals withdrawn from the experiment showed a statistically significant replacement of the artificial defect with bone tissue with signs of restoration of the cortical plate. The analysis of the CT results indicates that this method is sufficiently informative in assessing the regeneration of the trabecular structure of bone tissue. The study (MRI) of the bone material obtained from the animals participating in the experiment showed that when the osteoinductive material was integrated, the defect zone was replaced by 90%. In the projection of the defect, the newly formed tissue of a homogeneous structure was determined, corresponding in density to bone tissue with a high degree of mineralization. There was a complete restoration of bone tissue in the projection of the defect.