Introduction: Infectious diseases are still one of the main causes of high morbidity and mortality in tropical Indonesia. One of the causes of this disease is the staphylococcus aureus bacteria. Red dragon fruit peel contains potentially antibacterial compounds such as flavonoid, alkaloid, saponin, tannin dan terpenoid. The purpose of this study is to determine the antibacterial activity of ethanolic extract of red dragon fruit peel against staphylococcus aureus ATCC 25923. Method: The method used is true experimental post test only control group design. The activity of ethanol extract of red dragon fruit skin was tested in various concentrations (25%, 50%, 75%, and 100%) against staphylococcus aureus ATCC 25923 by measuring the inhibition zone diameter and minimum inhibitory concentration (MIC). Result: The results of this study show that red dragon fruit peel ethanolic extract has antibacterial activity against staphylococcus aureus ATCC 25923 ith the average diameter of inhibition zone ranging from 8.25 mm-12.5 mm. The MIC is obtained at concentration of 25%. Kruskal-Wallis test found a significant comparison with a value of p = 0,000 (p value <0.05). Mann-Whitney test showed that there were significant differences between each concentration, except the concentration of 50% did not have a significant difference with a concentration of 75%. Conclusion: The minimum inhibitory concentration (MIC) is produced by extract at a concentration of 25% and the best inhibitory zone produced by 100% concentration of red dragon peel ethanol extract.

Penyakit Jantung Koroner (PJK) adalah penyakit kardiovaskuler akibat penyempitan pembuluh darah koroner yang menyebabkan iskemia miokard, sehingga mengakibatkan apoptosis sel. Kunyit mengandung senyawa yang berperan sebagai anti inflamasi, seperti kurkumin.  Tujuan: Menentukan pengaruh kandungan kurkumin pada kunyit (Curcuma longa) terhadap kadar Ischemia Modified Albumin (IMA). Metode: Desain penelitian ini adalah rancangan post-test only control group dengan menggunakan tikus wistar jantan sebanyak 30 ekor yang terbagi ke dalam 5 kelompok yaitu, kelompok 1 kontrol negatif, kelompok 2 kontrol positif, kelompok perlakuan 1, 2, dan 3. Kelompok perlakuan masing-masing mendapatkan ekstrak kunyit dengan variasi dosis 50, 100, dan 200 mg/kgBB. Pemeriksaan kadar IMA dalam serum darah menggunakan teknik ELISA. Data dianalisis dengan uji One-Way Anova. Hasil: Kadar IMA pada masing masing kelompok adalah kelompok 1 kontrol negative = 300,471 ng/mL, kelompok 2 kontrol positif = 333,357 ng/mL, kelompok perlakukan 1 dosis 50mg/kg = 232,317 ng/mL, kelompok perlakukan 2 dosis 100 mg/kgBB = 173,385 ng/mL, dan kelompok perlakuan 3 dosis 200 mg/kgBB =  217,358 ng/mL. Hasil analisis statistik menunjukkan tidak terdapat perbedaan yang bermakna kadar IMA antara semua kelompok penelitian, yakni kelompok kontrol positif, kontrol negatif, maupun kelompok perlakuan (p>0,05). Berdasarkan Independent  t-test menunjukkan terdapat perbedaan yang bermakna kadar IMA antara kelompok perlakuan ekstrak kunyit 100 mg/kgBB, 200 mg/kgBB dengan kelompok kontrol positif. Simpulan: Ekstrak kunyit berpengaruh terhadap kadar IMA.Kata kunci: IMA, kunyit, kurkumin

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Background: Infection is one of the main causes of disease in tropical regions like Indonesia. One of them can be caused by bacterial infection of Staphylococcus epidermidis. Staphylococcus epidermidis is an opportunistic bacterium that attacks individuals when the body's immune system is weak. The incidence of bacterial resistance to antibiotics that already exist so that requires an alternative treatment, one of which is the use of temulawak rhizome extract (Curcuma xanthorrhiza Roxb). Temulawak rhizome is one of the spices which is still often used as traditional medicine among Indonesian people. Temulawak rhizome extract is known to have a variety of chemical contents with active compounds in the form of essential oils xanthorrhizol and curcumin which can affect the rate of bacterial growth.Methods: This study aims to determine the antibacterial activity of temulawak rhizome extract on the growth of Staphylococcus epidermidis bacteria in vitro. The method used in this study is the true experimental post test only control group design. Samples were divided into four treatment concentrations such as the extract concentration of 25%, 50%, 75%, and 100% of temulawak rhizome which was tested by agar diffusion method (Kirby-Bauer).Result: The results of the analyze of variant (ANOVA) test showed a significant difference (p = 0,000). The temulawak extract could inhibit bacterial growth with a medium inhibitory response (5-10 mm). Temulawak rhizome extract showed the greatest inhibition at 100% concentration with an average inhibition zone diameter of 9.20 mm.Conclusion : The extract of temulawak rhizome has antibacterial activity. The higher concentration of temulawak rhizome extract (Curcuma xanthorrhiza Roxb), the greater ability to inhibit the growth of Staphylococcus epidermidis bacteria.