Introduction: The regeneration of dental pulp tissue using human dental pulp stem cells (HDPSCs) has attracted increasing attention in recent years. Recent studies have suggested that several factors such as photobiomodulation (PBM) and vitamin D affect the proliferation and differentiation of HDPSCs. Therefore, the present study evaluated the effects of PBM and vitamin D on odontogenic differentiation of HDPSCs for dentin -like tissue formation. Methods: HDPSCs were collected, isolated, and characterized and then divided into six groups: group I, control; group II, vitamin D (10-7 Mol); group III, irradiation at 1 J/cm2 of 810 nm diode laser; group IV, irradiation at 1 J/cm2 and culture with vitamin D; group V, irradiation at 2 J/cm2 , and group VI, irradiation at 2 J/cm2 and culture with vitamin D, cell viability assay was measured through MTT. Alkaline phosphatase (ALP) enzyme activity and mRNA levels of vascular endothelial growth factor (VEGF), bone morphogenic protein-2 (BMP-2), and dentin sialophosphoprotein (DSPP) were also assessed. Results: PBM at 1 and 2 J/cm2 combined with vitamin D significantly promoted HDPSCs proliferation through MTT assay and odontogenic differentiation through gene expression of VEGF, BMP-2, and DSPP levels (P<0.0001). Conclusion: PBM at 2 J/cm2 combined with vitamin D enhanced the HDPSCs proliferation and odontogenic differentiation and thus could be a novel strategy for dentin regeneration in dentistry.

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JSON Web Token (JWT) is a compact and self-contained mechanism, digitally authenticated and trusted, for transmitting data between various parties. They are mainly used for implementing stateless authentication mechanisms. The Open Authorization (OAuth 2.0) implementations are using JWTs for their access tokens. OAuth 2.0 and JWT are used token frameworks or standards for authorizing access to REST APIs because of their statelessness and signature implementation and JWT tokens are based on JSON and used in new authentication and authorization protocols in OAuth 2.0 because of their small size. When refresh tokens are stored in cookies, the size limit of a cookie or URL may be quickly exceeded. There may be refresh tokens for accessing users and getting the refresh token is a bit more complicated and refresh tokens in the browser require additional security measures and the attacker steals a refresh token and attempts to use it after the application has already used it. This implies that the attacker was able to steal a refresh token from the application. If the refresh token can be stolen, then so can the access token, even short token lifetimes can still lead to major abuse scenarios. In this article, we discuss the security properties of refresh tokens in the browser and the pattern to secure JWT tokens in the web front-end better. We propose a Backend for Frontend (BFF) pattern, where the token handling is deferred to the server-side component to a secure token that provides a lot of flexibility to the client-side.

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