No abstract

No abstract

The phenanthridine family is widely found in medicinal chemistry and material science because of the biological activity and the presence in a variety of significant natural products and synthetic dye-stuffs. The phenanthridine has many clinical application like anticancer agent, antibacterial, antiprotozoal, pharmaceutically, and optoelectronic properties. Many methods have been reported for the synthesis of phenanthridine and phenanthridine alkaloids such as Pd catalyzed C-C bond forming. Reaction involving C-H activation , Radical, Microwave-assisted , transition metal catalyzed, one- pot cascade, benzyne mediated, photochemical, hypervalent iodine promoted ,etc. Here we summarized the literature data from 2014 to present concerning a novel or improved synthetic approaches.

The functionalization of organic molecules with the Schiff bases having benzothiazole moiety has grown rapidly due to its multiple therapeutic and pharmacological properties. They have driven enormous studies on their stereochemistry, bioactivity and synthetic attempts. The benzothiazole moiety is infinitesimal but broadly used for industrial purposes and also exhibits a broad range of biological activities. Study carried out on Schiff bases having benzothiazole had well-known promising activities like antimicrobial, antimalarial, antifungal, antitubercular, antiviral, antitumor, analgesic, anti-inflammatory and many more. This review brings forward a systematic and comprehensive survey of the reactivity and biological properties associated with the Schiff bases-benzothiazole derivatives and their analogs.

No abstract