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In a field trial on a farm in Turkey, we tested whether specific egg-yolk antibodies had a prophylactic effect on neonatal diarrhea. Owing to its antibody spectrum, this egg powder was very suitable for this farm since mainly rotavirus was identified. Regardless of the dosage (2 g, 4 g, or 8 g egg powder), the calves (n = 164) which received specific egg-yolk antibodies via the whole egg during the first 14 days of life showed significant improvements in risk and duration of diarrhea and in body weight gain compared with calves of the control group (n = 80) which had not received any egg powder. These significant differences in body weight still persisted after 3 months of life. The mortality risk in the control group amounted to 8.8%, while in all egg powder groups (n = 164) only one calf died as a result of diarrhea. Breed-dependent differences in the parameters were not observed.

Summary Objective: Prednisolone and antihistamines are highly potent drugs in the treatment of atopic dermatitis and widely used in humans and dogs. In some atopic patients in which antihistamines, corticosteroids or other drugs have already been administered intradermal testing (IDT) may be necessary. The aim of the present study was to compare the effects of cetirizine and prednisolone on IDT results. Material and methods: Thirty healthy dogs (average age 5.9 ± 0.6 years) were randomly assigned to three groups. Treatment groups were administered prednisolone (1 mg/kg BW daily, tapering dosage; group I), cetirizine (1 mg/kg BW daily; group II) and placebo (group III) respectively for one week. In the second week, none of the dogs received any medications. IDT was performed prior to drug administration and results obtained were considered as the baseline response. Second and third IDTs were performed at the end of the first and second week, respectively. Results: In groups I and II IDT reactivity was reduced at the end of first week (p < 0.05). After drug discontinuation the reactivity almost returned to baseline at the end of the 2-week period, with the exception of the prednisolone group for D. farinae. Conclusion: Prednisolone and cetirizine have significant effects on IDT reactions and must be withdrawn by veterinary practitioners up to 2 weeks prior to IDT.

This report describes an intestinal adenocarcinoma in a 13-year-old female lion (Panthera leo) from the zoo of Bursa, Turkey. The animal suffered from muscle atrophy, was presented to the Department of Internal Medicine with signs of anorexia, lethargy and abdominal distension, and a presumptive diagnosis of FIP was made. The lion did not respond to treatment and was euthanized for humane reasons. At necropsy, approximately 10 l serous ascites was observed in the abdominal cavity. A firm tumourous mass with grayish white cut surface was seen to invade all layers of the wall of the ascending colon. The tumour did not cause any luminal stricture, and no mucosal ulcerations were detected. In addition, numerous firm, grayish white nodules up to 1.5 cm in diameter were present on the peritoneal surface of the abdominal wall, omentum, diaphragm, mesentery and also on the serosal surfaces of stomach, spleen, uterus and vagina. Microscopically, a metastasizing mucinous type of a colonic adenocarcinoma with metaplastic bone formation was found. Peritoneal implants had similar features to the intestinal tumour except for the lack of metaplasic bone formations. Immunohistochemically, neoplastic cells were positive for CDX2, a marker for a human intestinal transcription factor in normal and neoplastic intestinal epithelial cells. However, cytokeratins 7 and 20, usually used in human diagnostics of intestinal adenocarcinomas, were negative, suggestive of an intestinal epithelial cell origin. Depending on the gross, histopathologic and immunohistochemical findings, the tumour was diagnosed as mucinous-type colonic adenocarcinoma. This is the first report of intestinal adenocarcinoma in lions.