Dose-dependent effects of specific egg-yolk antibodies on diarrhea of newborn calves

Özpınar, Haydar; Erhard, M. H.; Aytuğ, Nilüfer; Özpınar, Aysel; Baklaci, C; Karamuptuoglu, S; Hofmann, Andrea; Lösch, U.

doi:10.1016/0167-5877(95)00561-7

Cited by 22 publications

(9 citation statements)

References 15 publications

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“…Studies using both animal models and trials in field herds have been carried out. The groups of Erhard ( 179), Lösch (180)(181)(182), Yolken (183) and Kuroki (171,172) have performed a great part of the studies on the practical use of IgY. These studies confirmed that the treatment of diarrhoea in calves and piglets with specific egg yolk Abs has achieved significant prophylactic and therapeutic benefits.…”

Section: Igy For Therapeutical or Prophylactic Use In Veterinary Medimentioning

confidence: 93%

Chicken Egg Yolk Antibodies (IgY-technology): A Review of Progress in Production and Use in Research and Human and Veterinary Medicine

Schade

Calzado²,

Sarmiento³

et al. 2005

Altern Lab Anim

295

230

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The production of antibodies (Abs) in chickens and the extraction of specific Abs from egg yolk (IgY Abs) are increasingly attracting the interest of the scientific community, as demonstrated by the significant growth of the IgY literature. This review offers detailed and comprehensive information about IgY-technology, including: a) possibilities for hen keeping in accordance with the Three Rs principles; b) new insights into the IgY transfer mechanism from blood to yolk as a biological basis for the technology; c) the comparative characteristics of IgY Abs and IgG Abs; d) the high efficacy of the technique, in view of the extraordinary amount of IgY Ab produced by one hen in one year (between 20g and 40g IgY in total); e) comparisons between the efficacies of IgY Abs and IgG Abs (rabbit, sheep, mouse) in several immunological assays; f) immunisation protocols, as well as the most commonly used IgY-extraction procedures; g) new possibilities for application in human and veterinary medicine, including strategies for the treatment of Helicobacter pylori infection or fatal intestinal diseases in children, particularly in poor countries, for reducing the use of antibiotics, and, in Asia and South America, for producing Abs against snake, spider and scorpion venoms; and h) the use of IgY Abs in various fields of research, also taking into consideration recent developments in South America (particularly Argentina and Cuba) and in Asia.

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Section: Igy For Therapeutical or Prophylactic Use In Veterinary Medimentioning

confidence: 93%

Chicken Egg Yolk Antibodies (IgY-technology): A Review of Progress in Production and Use in Research and Human and Veterinary Medicine

Schade

Calzado²,

Sarmiento³

et al. 2005

Altern Lab Anim

295

230

View full text Add to dashboard Cite

show abstract

“…A large number of authors have stated that egg yolk antibodies administered to different types of animals can be used for the prevention and therapy of infectious diseases, especially diseases affecting the gastrointestinal tract. Yolk antibodies have been used successfully in cases of diarrhoea of unweaned piglets and newborn calves (Erhard et al., 1993; Kellner et al., 1994; Özpinar et al., 1996). In most of the scientific reports on mammals, clinical findings were linked directly to the protective effects of administered egg yolk antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…Authors working with egg yolk antibodies to control new born diarrhoea in calves (Erhard et al., 1993; Özpinar et al., 1996) or unweaned piglets (Wiedemann et al., 1990; Kellner et al., 1994) stated that orally administered specific yolk antibodies reach the intestine unchanged similar to the colostral antibodies in the first days of life (Wiedemann et al., 1990).…”

Section: Discussionmentioning

confidence: 99%

Effect of Orally Administered Egg Yolk Antibodies onSalmonella enteritidisContamination of Hen's Eggs

Gürtler

Methner²,

Kobilke

et al. 2004

Journal of Veterinary Medicine, Series B

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Summary The influence of oral application of anti‐Salmonella egg yolk antibodies on the in vivoSalmonella contamination rate of eggs laid by experimentally infected hens was investigated. Antibody containing egg powder was obtained by spray drying of whole egg contents from hens immunized with two Salmonella enteritidis (S. enteritidis) strains. The whole egg powder was administered orally to a laying hen group. The effects of anti‐Salmonella egg yolk antibodies in this experimental group were compared with a control group. In experiment 1, hens were infected orally with 2 × 109 colony‐forming units (CFU) of S. enteritidis per hen, compared with experiment 2 with an infection dose of 2 × 108 CFU/hen. Eggs laid by the experimental and the control groups were monitored for S. enteritidis; egg shells, the albumen and the egg yolk were sampled separately. Results indicated that the rate of Salmonella contaminated eggs of laying hens – experimentally infected with S. enteritidis at an infection dose of 2 × 108 CFU/hen – could be reduced by oral administration of whole egg powder containing S. enteritidis‐specific antibodies. In the experimental group 13.3% of the eggs were Salmonella positive, which was significantly different from 29.4%Salmonella‐positive eggs in the control group (P ≤ 0.001). The use of antibody containing whole egg powder as a feed additive may be an alternative way to reduce the Salmonella contamination rate of hens eggs. The protective effect may have been due to the antibodies raised by vaccination of hens against S. enteritidis.

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“…IgY has been shown to successfully control intestinal infection of rotavirus in newborn calves and mice [ 70 – 73 ]. Studies with pigs have been reported and similar positive results were obtained [ 74 ].…”

Section: Antiviral and Performance Effectsmentioning

confidence: 99%

Chicken egg yolk antibodies (IgY) as non-antibiotic production enhancers for use in swine production: a review

Wang

Zhen

et al. 2015

J Animal Sci Biotechnol

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In recent years, the use of in-feed antibiotics for growth and disease prevention in livestock production has been under severe scrutiny. The use and misuse of in-feed antibiotics has led to problems with drug residues in animal products and increased bacterial resistance. Chicken egg yolk antibodies (IgY) have attracted considerable attention as an alternative to antibiotics to maintain swine health and performance. Oral administration of IgY possesses many advantages over mammalian IgG such as cost-effectiveness, convenience and high yield. This review presents an overview of the potential to use IgY immunotherapy for the prevention and treatment of swine diarrhea diseases and speculates on the future of IgY technology. Included are a review of the potential applications of IgY in the control of enteric infections of either bacterial or viral origin such as enterotoxigenic Escherichia coli, Salmonella spp., rotavirus, porcine transmissible gastroenteritis virus, and porcine epidemic diarrhea virus. Some potential obstacles to the adoption of IgY technology are also discussed.

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Dose-dependent effects of specific egg-yolk antibodies on diarrhea of newborn calves

Cited by 22 publications

References 15 publications

Chicken Egg Yolk Antibodies (IgY-technology): A Review of Progress in Production and Use in Research and Human and Veterinary Medicine

Chicken Egg Yolk Antibodies (IgY-technology): A Review of Progress in Production and Use in Research and Human and Veterinary Medicine

Effect of Orally Administered Egg Yolk Antibodies onSalmonella enteritidisContamination of Hen's Eggs

Chicken egg yolk antibodies (IgY) as non-antibiotic production enhancers for use in swine production: a review

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