Prepared movements are more efficient than those that are not prepared for. Although changes in cortical activity have been observed prior to a forthcoming action, the circuits involved in motor preparation remain unclear. Here, we use in vivo two-photon calcium imaging to uncover changes in the motor cortex during variable waiting periods prior to a forepaw reaching task in mice. Consistent with previous reports, we observed a subset of neurons with increased activity during the waiting period; however, these neurons did not account for the degree of preparation as defined by reaction time (RT). Instead, the suppression of activity of distinct neurons in the same cortical area better accounts for RT. This suppression of neural activity resulted in a distinct and reproducible pattern when mice were well prepared. Thus, the selective suppression of network activity in the motor cortex may be a key feature of prepared movements.

Modeling eye movement indicative of expertise behavior is decisive in user evaluation. However, it is indisputable that task semantics affect gaze behavior. We present a novel approach to gaze scanpath comparison that incorporates convolutional neural networks (CNN) to process scene information at the fixation level. Image patches linked to respective fixations are used as input for a CNN and the resulting feature vectors provide the temporal and spatial gaze information necessary for scanpath similarity comparison. We evaluated our proposed approach on gaze data from expert and novice dentists interpreting dental radiographs using a local alignment similarity score. Our approach was capable of distinguishing experts from novices with 93% accuracy while incorporating the image semantics. Moreover, our scanpath comparison using image patch features has the potential to incorporate task semantics from a variety of tasks.

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