Cerebral venous thrombosis associated to the monoclonal gammopathy of undetermined significance has been rarely reported. In this paper, we discuss the case of 68-year-old man who presented repeated comitial. A cerebral Magnetic Resonance Imaging (MRI) showed cerebral venous thrombosis. The only biological abnormality highlighted was high level of monoclonal gammaglobulin. The coexistence of cerebral venous thrombosis and the monoclonal gammopathy of undetermined significance were fortuitous without causality links. French Abstract La thrombose veineuse cérébrale est rarement associée à une gammapathie monoclonale de signification indéterminée. Dans cet article, nous discutons le cas d’un homme de 68 ans, qui présentait une crise convulsive récidivante. L’IRM cérébrale montrait une thrombose du sinus sagittal supérieur. La seule anomalie biologique mise en évidence était l’augmentation monoclonale des gammaglobulines. La coexistence entre la thrombose veineuse cérébrale et la gammapathie monoclonale de signification indéterminée était fortuite sans lien de causalité. Mots-clés : Thrombose veineuse cérébrale, Gammapathie monoclonale de signification indéterminée, Association Morbide, Madagascar

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Eosinophilic granulomatosis with polyangitis (EGPA), formerly known as Churg-Strauss syndrome, with antineutrophil cytoplasmic autoantibodies (ANCA) is a rare vasculitis. The CANCA is mainly antibodies to proteinase-3 and the P-ANCA is antibodies to myeloperoxidase (MPO). The EGPA with C-ANCA with antibodies anti-MPO has never been described in Subsaharan Africa. Medical investigations allowed excluding infectious diseases, malignancies and other rheumatic affections. Thus, clinical and paraclinical data suggested an atypic EGPA with MPO-C-ANCA. In our knoweledge, we reported here the first case of EGPA wtih MPO C-ANCA from Madagascar. The EGPA was succesfully controled with steroid treatment.

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