The authors followed up the incidence of permanent hypothyroidism in 35 patients with subacute thyroiditis (SAT) in their past history. The investigations were made one to four years after the acute episode. Ten of these presented repeated recurrences despite the therapy with glucocorticoids. The investigations included serum determination by RIA of T4, T3, TSH and thyroglobulin as well as of circulating thyroid antibodies. Permanent hypothyroidism subsequent to SAT occurred in two patients. In one of them it occurred following thyroid surgery performed for repeated recurrences. Both patients presented high levels of circulating thyroglobulin antibodies suggesting a possible transition to autoimmune thyroiditis. In the authors' opinion permanent hypothyroidism is likely to develop after SAT only in association with an autoimmune process or after thyroid surgery.

145Recently, an impairment of glucose assimilation and insulin output produced by calcitonin has been demonstrated in men (Zieg/er, Bel/winkel, Schmidtchen and Minne 1972). A possible competitive action of calcitonin to insulin was studied by means of isolated diaphragm museie method (Gemil/ 1941, Vallanc~Owen 1954. The diaphragms were excised from male rats weighing 100 gm and incubated in 2 ml KrebsHenseleit buffer under a gas phase (95% oxygen -5% carbon dioxide) for 90 minutes with an initial glucose content of 3 mg/mL Glucose uptake was determined with Somogyl's reagent, and the results are expressed in PI!, of glucose/l0 mg dried diaphragm.Synthetic salmon calcitonin (CTS) had no effect on the spontaneous glucose uptake

SLE is the prototype of connective tissue diseases that can present the complete spectrum of neurologic and psychiatric disorders, cognitive dysfunction, depression and anxiety being more prevalent compared to general population, with an input on patients� prognosis and quality of life. In this study we aimed to determine the presence of cognitive dysfunction, anxiety and depression in a cohort of SLE patients, and their relationship to disease activty and quality of life. We determined the presence of these neuropsychyatric manifestations in signfficant percentages, directly correlated to disease activity and with an impact of quality of life. Our results lead to its extension, with multicentric contribution, and underline the necessity and benefit of a careful and periodical neuropsychiatric examination, in order to recognize the clinical patterns in early stages, apply the proper therapeutic measures, quantify the future damage and improve the outcome of these patients.

Background Data on the readiness of the general emergency departments (EDs) in Canada to care for children requiring emergency care are limited. Recent evidence suggests an inverse association between pediatric readiness of the general ED and mortality. Objectives To assess the baseline pediatric readiness of the general EDs in the province of Manitoba, Canada, to care for acutely ill and injured children. Methods This was a cross-sectional survey study conducted between 2019 and 2020. We used a validated pediatric readiness research checklist to obtain information on the six domains of the general EDs in Manitoba in the fiscal year 2019. A general ED that managed acutely ill patients (0–17th birthday), except for psychiatric cases (up to the 18th birthday), was defined as eligible. We performed a descriptive analysis using the weighted pediatric readiness score (WPRS) based on a 100-point scale. The factors associated with the total WPRS were examined in linear regression models. Results Of the 42 eligible general EDs, 34 centers participated with a participation rate of 81%. However, only 27 general EDs plus one specialized children ED (28, 67%) completed the survey. The overall median WPRS (/100) attained by the general EDs was 52.34 (interquartile range [IQR] = 10.44). The only specialized children ED in Manitoba achieved a score of 89.75. Over half (15, 55.6%) of the general EDs scored 50 or more. The mean volume of the general ED that participated was 4010.9 (± SD 2137.2) pediatric general ED visits/year. The average scores attained in the domains such as coordination of patient care, general ED staffing and training, and quality improvement were low across the five Regional Health Authorities. The general ED volume was directly associated with the total WPRS, regression coefficient, β = 0.24 (95% CI 0.04–0.44). Neither the capacity of the general ED to receive pediatric patients from a nursing station, β =  − 0.07 (95% CI − 0.28–0.14), nor the capacity to admit pediatric patients that visited the general ED, β =  − 0.03 (− 0.23–0.17) was associated with the total WPRS. Conclusions The pediatric readiness of the general EDs across Manitoba is comparable to other Canadian region, yet some domains need to be improved.

Urinary tract infections represent a frequent, infectious casuistry of the neurologic patient, often recurrent, with the significant involvement of multidrug-resistant bacteria (MDRs). A retrospective study, during the period 01.01.2018-31.12.2018, in the Clinical Neurology Hospital in Craiova, on a group of 334 Px with urinary tract infections and proven microbial etiology (positive urocultures), for whom antibiograms were performed using KIRBY-BAUER disk diffusion test. The duplicates and samples considered contaminated were excluded from the study. Urinary tract infections are frequently encountered in the neurologic patient, the major etiology being represented by E. coli; the risk of multidrug-resistance is not to be neglected, Klebsiella pn being the most common in such a situation.