The aim. The study encompassed some aspects related to perfumes use, which can potentially influence the individual perfume choice, in particular, among different age groups of the Ukrainian population. Factors related to perfumes choice, the state of awareness of respondents regarding quality, safety, and existing stereotypes regarding the characteristics of perfumes and potential harmful effects on the human body were investigated. Materials and methods. The analysis was performed on a sample of 124 residents of Ukraine. Respondents, who were randomly selected, were offered a questionnaire, developed by us, which included 15 items on the demographic characteristics of the subjects and questions related to the perfume use of and stereotypes about them. The Pearson chi-squared (χ2) test was used to analyze the relationships between qualitative characteristics. Results and discussion. About 98 % of surveyed persons in Ukraine use perfumery. Associations were found between age and the probability of purchase by the study participants of non-original perfume products and awareness of the safety of various perfume products. It has been established, that the determining factors when choosing a perfume is a certain scent, while the brand is given secondary importance. An increase in the effect of the brand in older age groups of the population has been demonstrated. Behavioral features of perfume use have been established: in younger women, it is associated with increased self-esteem and the influence of social networks, with age, the focus shifts to the desire for a positive effect on the mood from the use of a certain fragrance. However, in all age groups, the main purpose of perfume using was to improve the emotional state. Middle-aged women are more democratic in choosing perfumery with a specific gender orientation. Conclusions. For the first time in Ukraine, a pilot study was conducted to find possible associations between some biological, behavioral and demographic characteristics and the perfume use. Such factors as age and education level are promising for further analysis of the selected issues

With the purpose of complex research of soft medicinal product-gel for treatment of wounds in the II phase of the wound process the assessment of the indicators, which are specified in the corresponding normative documents and allow to control comprehensively the quality of the product developed during its shelf-life, has been carried out. During the experiment the methods regulated by such normative documents as the SPhU and SUC 24.5-37-103:2004 "Cosmetic Gels" have been used. The gel developed was stable according to the experimental indicators within 2 years under the modes studied: the pH value was stable for all the series of the gel samples and was within the range of 5.0-7.5; the quantitative content of the substances was within the QCM project; the mass of a gel tube did not changed. After centrifugation the gel breaking was not observed, the temperature change did not also affect the stability of the product developed during the study. The data obtained allowed to recommend the shelf-life of 2 years at the room temperature in aluminium tubes. Based on the study of the structural-mechanical properties of the gel samples during storage the complete flow rheograms have been built, according to their data it can be seen that during the period under research the gel samples have not practically changed their rheological characteristics. It indicates the strength of the gel structure and the right choice of active substances and excipients, their concentrations, and the rational technology. The mechanical stability values of the product developed during the whole storage period have not practically changed, and it indicates the drug stability in the process of storage, as well as the absence of interaction between the active substances. According to the research data both after preparation and during the long storage of the gel the indicators obtained characterize it as a structured system with positive consumer and structural-mechanical properties.

The development of many chronic infections, including skin diseases, is caused by bacteria growing in the form of biofilms. Bacterial biofilms provide beneficial survival mechanisms that determine virulence, disease pathogenesis, or resistance of the pathogen to antibiotics. As shown by a large number of studies, biofilms play an important role in the pathogenesis of dermatological diseases, including atopic dermatitis. The close relationship between the microbial biofilm that colonizes the skin surface and the negative consequences for human health makes the skin microbiome an object of therapeutic intervention in dermatological pathogenic processes. The work aims to study the effect of dermatological phytogel on the ability of microorganisms to form biofilms. The objects of research were samples of gel containing dry walnut leaf extract with the sum of tannins in terms of gallic acid and dry matter 30 mg/100 g of gel, dry nettle extract with the sum of hydroxycinnamic acids in terms of chlorogenic acid, and dry matter 20 mg/100 g of gel, dry thyme extract with the sum of flavonoids in terms of rutin and dry matter 35 mg/100 g of gel both monocomponent and combined. The study of the ability of individual plant components of phytogel samples N 1, N 2, N 3 and samples of combined phytogel N 4, N 5, and N 6 to influence biofilm formation have shown that the most pronounced decceleration of biofilms formation was registered in the gel sample with phytocomplex N 4 and was 19.7–20.7% to S. aureus, E. coli, P. aerugenosis and C. albicans respectively. The activity of the gel sample with phytocomplex N 4 was 1.3–1.4 times higher than that of monocomponent gel samples N 1, N 2, and N 3. When determining the ability of the test samples to destroy biofilms, it has been found that the gel sample with phytocomplex N 4 showed the greatest activity, which exceeded the specified properties of samples N 5 and N 6 by an average of 1.2 and 1.8 times. The activity of single-component gel samples N 1, N 2, and N 3 was lower in S. aureus, E. coli, P. aerugenosis and C. albicans biofilm destruction. The conducted studies prove the feasibility of further study of the combined gel with the phyto complex № 4 containing dry walnut leaf extract with the sum of tannins in terms of gallic acid and dry matter 30 mg/100 g of gel, dry nettle extract with the sum of hydroxycinnamic acids in terms of chlorogenic acid, and dry matter 20 mg/100 g of gel, dry thyme extract with the sum of flavonoids in terms of rutin and dry matter 35 mg/100 g of gel.

ДосліДження ринку лікарських препаратів, які застосовуються Для місцевого лікування Дерматитів Метою роботи є аналіз ринку лікарських препаратів (ЛП), які представлені на фармацевтичному ринку України та застосовуються для місцевої терапії дерматитів, за фармакотерапевтичними групами, складом, формами випуску та країною походження для обґрунтування необхідності розробки нового ЛП на основі біологічно активних речовин лікарської рослинної сировини (ЛРС). Результати. Проведено аналіз ринку ЛП, які представлені на фармацевтичному ринку України та застосовуються для місцевої терапії дерматитів за виключенням ЛП груп D01 (Протигрибкові препарати для застосування в дерматології), D06 (Антибіотики і хіміотерапевтичні препарати) і D07 (Кортикостероїди), що обумовлено попереднім складом препарату, який розробляється. Було проаналізовано склад ЛП, зареєстрованих в Україні, в залежності від спрямованості фармакотерапевтичної дії та за кількістю компонентів (монопрепаратів або комбінованих), їх розподіл за формами випуску, країнами-виробниками, наявністю компонентів ЛРС у складі. Висновки. Аналіз асортименту допоміжних ЛП, які застосовуються для лікування дерматиту, показали незначну частку ЛП комплексної дії, які дозволяють попередити розвиток захворювання або прискорити одужання, та відсутність засобів, здатних водночас забезпечити косметологічний догляд за шкірою. Так, комбіновані ЛП серед досліджуваних ЛП становлять лише 8 %, ЛП на основі ЛРС-3 %. Понад 36 % ЛП досліджуваних груп представлені у формі розчину, 31 %-у формі мазі. Продукція вітчизняних виробників у досліджуваних групах становить 86 % серед зареєстрованих найменувань ЛП. Перспективою подальших досліджень може бути пошук ефективних складових на основі ЛРС для створення ЛП для місцевого лікування проявів дерматиту.