Ascites occurs in about 60 % of patients with cirrhosis within 10 years of diagnosis. Laparocentesis is the preferred first-line therapy in patients with cirrhosis and massive tense ascites, allowing more than 5–6 liters of ascitic fluid to be removed at one time. The search for informative prognostic factors and the development of a method for predicting unfavorable outcomes of repeated laparocenteses in patients with ascites are relevant to timely refer this contingent of patients to perform TIPS.The purpose of the study was to develop and evaluate the diagnostic significance of a model for determining the probability of unfavorable outcomes of laparocentesis in patients with ascites on the background of liver cirrhosis.The results of treatment of 99 patients with the ascitic syndrome associated with intrahepatic portal hypertension were studied. The multiple regression analysis using the binary response logit model was carried out to calculate the prediction models. The analysis of the treatment results of patients with liver cirrhosis and ascites by the laparocentesis method revealed a number of factors that influence the onset of an unfavorable outcome. 2 models with the inclusion of initial variables are the most promising for forecasting. Model A includes: patient weight, serum-ascites total protein gradient, hyponatremia; model B: MELD-Na score, serum-ascitic total protein gradient, patient weight. The developed prediction method is highly informative, effective, easily applicable, and can be widely used in clinical practice.The ability to predict an unfavorable outcome in patients with portal hypertension and ascites after laparocentesis allows for a personalized approach in the process of timely selection of more effective, but also more expensive treatment methods, such as TIPS, which will help us to increase the therapy effectiveness and the survival of this cohort of patients.

COVID-19 causes an acute and often severe form of viral pneumonia. Aim of the study: To evaluate the long-term results of treatment of COVID-19-associated pneumonia according to control computed tomography findings in patients of Grodno region. Material and methods. A retrospective analysis of medical records of 170 patients of Grodno University Clinic was carried out. The long-term results of treatment of COVID-19-associated pneumonia in 20 patients were evaluated. Results. The average age of the patients was 59 years. The patients with a moderate form of the disease accounted for 77.6%. Respiratory failure was noted in 75.3% of cases. According to computed tomography of the chest, all patients had bilateral interstitial lung lesions of varying degree: CT1 – 28.8%, CT2 – 51.2%, CT3 – 17.6%, CT4 – 2.4%. Conclusions. Analysis of the long-term results of treatment according to CT data after 3-5 months showed that complete recovery was achieved in 35.0% of patients, and interstitial changes in the lungs persisted in 65.0% of cases. After 6-12 months, 3 patients achieved complete recovery, and 2 patients had minimal interstitial changes.

Metabolic consequences of introduction of dinyl on the concentration of free amino acids and their derivatives in animal’s tissues have been investigated in experiment on rats. The influence of taurine which was introduced together with dinyl on the spectrum of determined parameters also has been investigated. It has been revealed, that the peripheral action of taurine, which was introduced together with dinyl, is realized through the activation of the anabolic processes. The changes in tissues of the various departments of the brain at the animals receiving dinyl can have the relationship with clinical presentations of intoxication of dinyl. The course introduction of taurine on this background causes of the considerable changes in the concentration of the transmitter amino acid, biogenic amines, their metabolites and precursors. The analysis of the received data allows to make the conclusion about adaptive importance of observable changes. They confirm a role of taurine as compound optimizing the metabolic processes in the conditions of metabolic stress, both in the peripheral tissues, and the central nervous system.

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