It was investigated combined effect of passive smoking and reduced caloric nutrition during pregnancy without and against the background of the use of a new drug composition based on L-carnitine, hydrochloride and glycine with protective properties on the structural and functional changes in the placenta of female rats. The obtained results make it possible to consider this composition as promising in terms of creating a drug for primary prevention of gestational conditioned endocrinopathies.

In the experiment on Wistar rats was studied age dynamics of body weight in the postnatal period in the offspring of gestational stressed mothers, which was born with low weight and reduced levels of leptin in the blood plasma. It was shown that adult offspring of stressed mothers have increased body weight and visceral fat mass, increased levels of leptin in the blood compared to the offspring of intact mothers. However, by the number of food consumed offspring of stressed mothers did not differ from intact offspring. Long-term injection of exogenous leptin does not affect the eating behavior of offspring of stressed mothers, although inhibits the eating behavior the intact animals. It was concluded about availability of «economic type» energy metabolism and insulin resistance in the hypothalamic structures of offspring of gestational stressed mothers

Встановлено антенатальне походження та патогенетична спорiдненiсть ожирiння та остеопатiй. Розглянута участь лептину в формуваннi цих патологiй. Показано, що достатньо високий рiвень лептину, притаманний нащадкам гестацiйно стресованих матерiв, активує хондро- та остеогенез, пiдсилюючи репаративнi ефекти естрогенiв в кiстковiй тканинi. Разом з цим надмiрне зростання рiвня системного лептину є причиною патологiчних змiн хрящової та кiсткової тканини, що призводить до їх склерозування та формування остеофiтiв.

The study was aimed at investigation of distinctive features of feeding behaviour and fat tissue formation in the reproductive aged female rats whose mothers were stressed in the first tirm of the pregnancy. It has been shown that adult stressed offspring had higher body mass and the visceral fat tissue. The influence of stress factors in postnatal life resulted in the increased body mass and mesenteric fat weight along with the decreased food intake. It has been proposed that the neuroendocrine system change in the offspring of stressed mothers led to the change of the energy metabolism and the development of obesity

A comparative study of the histostructure of adipose tissue in females was performed rats - offspring of intact and gestational stressed mothers in the basal state and after the action of stress factors. It was found that the stress of mature offspring leads to the formation of a hypertrophic type of obesity in intact animals and provokes adipocyte hyperplasia and adipose tissue inflammation in rats stressed during the antenatal period.