It has been shown that gestational stress of mothers leads to the birth of offspring with decreased body weight and a low level of leptin in the plasma. In adulthood in these offspring with the same amount of consumed food weight and fat mass higher than the corresponding figures in the offspring of mothers intact. The sons of stressed mothers established the presence of leptin resistance hypothalamic structures regulate the body’s energy, which is manifested in the absence of anorectic’s effects at hyperleptinemia. Long-term intake of fructose in the body the children of stressed mothers leads to aggravation due to leptin resistance and gestational already at a young age can contribute to the development of obesity.

It was studied the specific multipotent performance synthetic compounds with a number of tryazolopyrymides 7-(3-hydroxyphenyl)-6-carbetoxy-5-methyl-4,7-dihydro[1,2,4]triazolo [1,5-a]pyrymidyn (NE-99) in thyroid and skeletal system of Wistar rats with experimental hypothyroidism. It was proved the positive effect of the compound YV-99 on the structure and functions of the thyroid gland and found it osteoprotect effect on bone lumbar vertebrae experimental animals. The obtained data allow us to consider this compound as a comprehensive tool to correct hypothyroidism thyroid and endocrine concomitant osteoporosis.

Встановлено антенатальне походження та патогенетична спорiдненiсть ожирiння та остеопатiй. Розглянута участь лептину в формуваннi цих патологiй. Показано, що достатньо високий рiвень лептину, притаманний нащадкам гестацiйно стресованих матерiв, активує хондро- та остеогенез, пiдсилюючи репаративнi ефекти естрогенiв в кiстковiй тканинi. Разом з цим надмiрне зростання рiвня системного лептину є причиною патологiчних змiн хрящової та кiсткової тканини, що призводить до їх склерозування та формування остеофiтiв.

In the literature of recent years it was widely discussed the issue of violation of the light mode as a risk factor for the formation of obesity — one of the leading symptoms of metabolic syndrome and type 2 diabetes. However, until the real time, the effect of the long round-the-clock illumination of different duration on histological and leptinproducing activity of adipose tissue remains unclear. Studies of the dynamics of weight indicators, histological characteristics and the level of leptin in the blood plasma of rats subjected to long round-the-clock illumination, for 3, 5 and 10 months, led to the conclusion that, originally, animals subjected to long round-the-clock illumination observed an activation of hyperplastic processes in adipose tissue and increasing of its leptinsynthesizing activity. Long round-the-clock illumination as an inducer of expressed hypopinealizm is the cause hypoplasia of adipose tissue, a sharp drop of its cytokineproducing function and the development of its nonspecific inflammation.

In the experiment on Wistar rats was studied age dynamics of body weight in the postnatal period in the offspring of gestational stressed mothers, which was born with low weight and reduced levels of leptin in the blood plasma. It was shown that adult offspring of stressed mothers have increased body weight and visceral fat mass, increased levels of leptin in the blood compared to the offspring of intact mothers. However, by the number of food consumed offspring of stressed mothers did not differ from intact offspring. Long-term injection of exogenous leptin does not affect the eating behavior of offspring of stressed mothers, although inhibits the eating behavior the intact animals. It was concluded about availability of «economic type» energy metabolism and insulin resistance in the hypothalamic structures of offspring of gestational stressed mothers