It has been shown that gestational stress of mothers leads to the birth of offspring with decreased body weight and a low level of leptin in the plasma. In adulthood in these offspring with the same amount of consumed food weight and fat mass higher than the corresponding figures in the offspring of mothers intact. The sons of stressed mothers established the presence of leptin resistance hypothalamic structures regulate the body’s energy, which is manifested in the absence of anorectic’s effects at hyperleptinemia. Long-term intake of fructose in the body the children of stressed mothers leads to aggravation due to leptin resistance and gestational already at a young age can contribute to the development of obesity.

It was investigated combined effect of passive smoking and reduced caloric nutrition during pregnancy without and against the background of the use of a new drug composition based on L-carnitine, hydrochloride and glycine with protective properties on the structural and functional changes in the placenta of female rats. The obtained results make it possible to consider this composition as promising in terms of creating a drug for primary prevention of gestational conditioned endocrinopathies.