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Introduction: It is well known that patients with schizophrenia are more sensitive to negative rather than positive feelings. In this study, we aimed to evaluate the degree of explicitly perceived threat against facial expressions of anger. We were also interested in the association between perceived threat, and both the objective intensity of facial expression of anger and the functional anatomy of the perceived faces.Method: Forty-eight patients with schizophrenia and 51 healthy controls were enrolled. Participants were presented a total of 21 sequences of anger including six different face images, which were selected from The Cohn-Kanade AU-Coded Facial Expression Database with emotions gradually changing from neutral to peak expression of anger. We measured when [time to threat (TtT)] and to which degree [Total perception of threat (TPoT)] threat was perceived by participants. The relation between perceived threat with the involvement of functional anatomic units among the face stimuli was also investigated.Results: TPoT was higher in the index compared to the control group. TtT was comparable in two groups and was associated with the severity of hallucinations among the index group. Total emotion intensity was lower in the sequences that evoked more threat in the index group. Functional contribution of the eyes and the upper lip to expression of anger were associated with TPoT among the index group. Conclusion:Schizophrenia subjects may be prone to perceive more threat in response to facial expression of anger. This proneness may be evident in response to less intense expression of anger, particularly via eyes and the upper lip.