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BackgroundIt was marked that children with increased BMI have high height due to insulin resistance or elevating insulin/IGF1. The Insulin resistant can be reason of cardio-vascular diseases.Aimto find the early detection of risk factors for cardiovascular diseases in children with height≥85 percentile age-sex normMethods854 children aged 3–17 y.o. were examined (included 87 with height≥85 percentile): by arterial stiffness device (TensioMed,Hungary) – 211; by 24 hour monitoring of ECG and blood pressure(Astrocard, Russia) – 92; by Polysomnography (Embla-S7000,USA)- 45; by system of continuous glucose monitoring (Guardian, USA) – 14 children.ResultsChildren with increased BMI and with height≥85 percentile in comparison with middle height had a significantly lower augmentation index, in 5 times more often – decreased diastolic blood pressure at night, lower level of high density lipoproteids; if they had obesity- the normal 24 hour dynamics of blood pressure was disappeared, if they had overweight- there was more longer QT interval at night, if they had sleep obstructive apnea-hypopnea syndrom there were some periods of glycemia less then 3.3 mmol/L at night.ConclusionsChildren with height≥85 percentile of age- and gender-based norms with increased BMI and, especially, with nasal obstruction have an additional risk of cardio-vascular diseases.Disclosure of InterestNone Declared

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The main characteristics of e-commerce, conceptual apparatus, development trends in domestic and foreign markets are considered. The main features characterizing Internet marketing are highlighted, recommendations are offered in the field of education to provide e-commerce market with specialists in accordance with the emerging new needs.