Background and aims
Endothelial dysfunction (DE)-a state of the vascular endothelium, which is accompanied by vazotonic, remodelic, anti-inflammatory and anticoagulant functions. The range of these disorders, the severity of each, and chronology of occurrence, the dynamic progression vary depending on the nosology pathology.
Methods
The investigated group included of 36 children (age -13,98 ± 0,16) with diagnosed primary arterial hypertension assotiated with DE. The scientific study was conducted in the Transcarpathian region of Ukraine.
Results
There were a significant difference in the levels of HDL (1,2 ± 0,31 mmmol/l to 69 ± 0,01 mmol/l, p < 0,001). In these children were indicated increase level of total cholesterol by LDL fraction to 2,35 ± 0,18 mmol/l. IA was in 2.97times higher in patients with mountainous region to according the control group (2.67 and 0.90). Changes in hemostasiogramme were identificated in 54% children (an increase of activated recalcification time (74,76 ± 5,06 s and 64,76 ± 2,04 s, p < 0.05), an increase of concentration of fibrinogen (17,53 ± 1,63 s and 11,32 ± 0,77 s, p < 0.001). According to our research were higher levels of Antiphospholipid IgM, than IgG (2,73 ± 0,34 to 2,03 ± 0,24, U/ml, p < 0.02), which varies within the reference values, but have different signs with dates of the control group.
Conclusion
These dates presented the risk of thrombogenesis, but non significant. The levels of IL-1 and IL -6 were in the range of control values, but have a tendency to decline, according to our data. This fact indicated about the decrease in production of interleukins of child’s organism in the mountains region.
