We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at 7q31 (rs4236601[A], odds ratio (OR) = 1.36, P = 5.0 × 10-10). We then replicated the association in sample sets of 2,175 POAG cases and 2,064 controls from Sweden, the UK and Australia (combined OR = 1.18, P = 0.0015) and in 299 POAG cases and 580 unaffected controls from Hong Kong and Shantou, China (combined OR = 5.42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG.

ABSTRACT. In this case report we present a female patient with recurrent urinary infection treated with trimethoprim/sulfamethoxazole, trimethoprim alone and ciprofloxacin. She developed adverse systemic symptoms and bilateral anterior uveitis following administration of the former two drugs, and in addition retinal haemorrhages after the use of trimethoprim. Uveitis and retinal haemorrhages are rare side effects of trimethoprim/sulfamethoxazole. To our best knowledge they have not been described as a side effect of trimethoprim alone. and in November they had cleared completely.The patient had several exposures of TMP/SMX and trimethoprim alone resulting in uveitis, but not when treated with ciprofloxacin.

The giant cells forming the Elschnig pearl mass after extracapsular cataract extraction are derived from lens epithelium. They are interconnected by gap-junction and desmosome-like structures. They stain homogenously and show few organelles. Active autolysis was demonstrated in some regions. The ultrastructural features of the giant cells in this type of secondary cataract share many of the characteristics of fiber cells. Because of profound changes in the environment postoperatively, these cells have developed other shapes and characteristics than normal lens fiber cells.

The ultrastructure of the lens capsule remnants in an eye with known fibrillopathy (pseudoexfoliation/exfoliation syndrome) subjected to an extracapsular cataract extraction (ECCE) and lens implantation 11 months earlier was examined. Lens epithelial changes typical in lenses with fibrillopathy were observed. The well-known fibrils radiated from pits in the lens epithelial cells, forming a deep layer in the lens capsule and the Busacca bushes on the capsule surface. It thus appears that the production of fibrillar material from lens epithelium may continue after ECCE and implantation of an intraocular lens. A possible connection between intracellular and extracellular fibrils was noticed.

The aim of this prospective study was to compare the clinical efficiency of two different kinds of intraocular lenses. By randomization, 40 patients received an intraocular lens either made of HEMA (hydroxyethylmethacrylate) or PMMA (Polymethylmethacrylate). 20 patients were assigned to each group. Age varied from 60 to 79 years. Follow up periode was 12 months. Posterior synechiae were more frequent in the PMMA group. This was statistically significant. One week postoperatively slightly more intraocular reaction was observed in the HEMA group. On the other hand PMMA lenses had higher incidence of precipitates. These differences however were not found to be statistically significant The analysis showed no difference in the visual acuity ratings in the groups at 12 months (VA 6/9 or better in 95%). Our conclusion is that the soft HEMA lens is a safe alternative to the rigid PMMA lens and probably more biocompatible to the eye.