Collagen (Col) is a naturally available material and is widely used in the tissue engineering and medical field owing to its high biocompatibility and malleability. Promising results on the use of Col were observed in the periodontal application and many attempts have been carried out to inculcate Col for gingival recession (GR). Col is found to be an excellent provisional bioscaffold for the current treatment in GR. Therefore, the aim of this paper is to scrutinize an overview of the reported Col effect focusing on in vitro, in vivo, and clinical trials in GR application. A comprehensive literature search was performed using EBSCOhost, Science Direct, Springer Link, and Medline & Ovid databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) collagen OR scaffold OR hybrid scaffold OR biomaterial AND (2) gingiva recession OR tissue regeneration OR dental tissue OR healing mechanism OR gingiva. Only articles published from 2015 onwards were selected for further analysis. This review includes the physicochemical properties of Col scaffold and the outcome for GR. The comprehensive literature search retrieved a total of 3077 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 15 articles were chosen for further review. The results from these articles indicated that Col promoted gingival tissue regeneration for GR healing. Therefore, this systematic review recapitulated that Col enhances regeneration of gingival tissue either through a slow or rapid process with no sign of cytotoxicity or adverse effect.

Introduction. Long term infection on periodontal tissue, mainly caused by anaerobic microbial, is not only related with tooth loss which lead to functional and esthetical impairment but also with increasing infection risk on other vital organs such as heart. Metronidazole is drug of choice for anaerobic bacterial infection. In this research, Metronidazole delivery system from carbonated apatite-based material was designed to increase the antibiotic therapeutic potential on local application as well as to promote tooth-supporting bone healing as a thin membrane to be applied on narrow periodontal tissue.Experimental. Metronidazole delivery system was prepared using different carbonate apatite composition on gelatin hydrogel system which was freeze-dried then polymerized by thermal treatment. Total 6 gelatin-carbonated apatite compositions were prepared: 10:0, 9:1, 8:2, 7:3, 6:4 and 5:5.The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). Water-content, air-water contact angle, tensile strength, Metronidazole-loading capacity, degradation profile and Metronidazole-release profile were studied to describe each composition potential as Metronidazole delivery system.Results and Discussion. Study on FTIR spectra and XRD confirmed preparation methods as standard procedures to prepare membrane formed delivery system-containing carbonate apatite. Descriptively from SEM, the film surface porosity was elevated by the increase of carbonate apatite composition. Tensile strength decreased was found by the increase of carbonate apatite composition. Water content, air-water contact angle, Metronidazole-loading capacity was not different significantly (P>0.05). Profile of degradation and Metronidazole-release from the membranes was different between compositions.Conclusions. This study results were essential to support next research on antibiotic potential using different anaerobic bacteria culture as well as bone regeneration potential on periodontal infection in vivo.

Purpose : To examine the effectivity of Banana (Musa paradisiaca L.) peel extract gel as adjuvant therapy for periodontitis. Sample: this experiment used 57 rats which divided into three groups; positive control group (received hyaluronic acid gel), treatment group (received banana peel extract) and negative control group (received base gel without active ingredient). Method: Aggregatibacteractinomycetemcommitanssus pension was injected on palatal surface of upper second molar of rats to induce periodontitis. The rats then treated with hyaluronic acid gel, banana peel extract gel and base gel based on its group on upper molar teeth twice a day. Histological evaluation was performed to evaluate treatment effectivity after 3, 5, 7, 14, and 28 days using Haematoxylin Eosin and Mallory Trichrome staining. Result: 10% banana peel extract increased angiogenesis, alveolar bone height and collagen density. Angiogenesis on treatment group was statistically different (p<0,05) from other groups, with means value of angiogenesis 10,89. Alveolar bone height measurement using morphometric method showed 379µm whereas histometric alveolar bone height showed 163,5µm. Collagen density also observed higher with the other group (51,24%). Conclusion: Banana (Musa paradisiaca L.) peel extract gel can be used as adjuvant therapy candidate for periodontitis.

Patients with Type 2 Diabetes mellitus (T2DM) were more prone to suffer from periodontitis due to unique alteration in host immune response. Application of curcumin oral gel as adjunctive therapy was expected to improve periodontal condition due to its anti-inflammatory properties. The objective of this study was to evaluate the effect of curcumin oral gel on periodontal inflammation in patients with T2DM. Sixteen periodontal pockets (n=16) from patients with T2DM were administered with curcumin oral gel using blunt cannula after periodontal curettage. Gingival Index (GI) and Periodontal Pocket Probing Depth (PPD) were evaluated a month after application. GI was assessed using visible sign of inflammation parameters including swelling, redness and bleeding upon probing. PPD was assessed using UNC-15 periodontal probe. The results were analyzed by Wilcoxon test (two related samples). The results showed that GI before treatment decreased by 51.61% a month post application. There was statistically significant difference (Sig 0.003) between GI mean before and after curcumin application. PPD decreased by 42.81% and showed statistically significant difference (Sig 0.000) by Wilcoxon Test. It is concluded that application of curcumin oral gel post curettage could decrease periodontal inflammation in patients with T2DM.