The aim —  to assess the method of adaptation of the oxygenator’s contact surface based on recepient’s blood serum albumin to the patient’s blood cells changes.Materials and methods. On the basis of the Surgical Center of SS «RPC PCM» SAD at the period from November 2016 to March 2017, 42 patients with AAH were operated. Patients were divided into two groups. Patients of the 1st group (30 patients, 24/6 person/women, respectively) were treated with AAH without processing adaptive composition (AdC). For patients of the 2nd group (12 patients — 9/3 patients/women respectively), AdC treatment of oxygenator was performed. The effectiveness of AdC treatment was monitored by a general blood analyzes and red blood cell state.Results and discussion. The use of AdC for treatment contact surface of oxygenator reduces the body’s response to it — a slight increase in WBC, a decrease in % of lymphocytes and granulocyte content in comparison with untreated version. In addition, in these cases, the absence of echinocytes and microcytes indicates adequate oxygen supply of red blood cells.Conclusions. Treatment AdC the contact surface of the oxygenator results in a decrease in the body’s response to it and increases the number of erythrocytes that contact with the gas exchange membrane.

The damage to erythrocytes during cardiopulmonary bypass (CPB) remains a recent problem. The aim of this research was to study the effect of fructose-1,6-diphosphate on the state of the erythrocyte membrane during CPB and the level of phosphorus in blood as a marker of the energy potential in the cell. Patients were divided into two groups. The control group 1 (Gr 1) consisted of 75 individuals. The group 2 (Gr 2) included patients to whom fructose-1,6-diphosphate (FDP) was administrated according to the developed scheme as follows 10 g of the drug was diluted in 50 ml of a solvent, 5 g of the drug was injected intravenously with the use of perfusor immediately before initiation of CPB at a rate of 10 ml/min and 5 g at the 30th minute of CPB (before the stage of warming) the same way. When comparing two groups the best results in hemolysis (p<0.01), mechanical (p<0.01). osmotic resistance of erythrocytes (p<0.01), the time of acid hemolysis (p<0.01) and the permeability of the erythrocyte membrane in postperfusion period were in Gr 2. Вefore cardiac surgery hypophosphatemia was detected in 18% out of 150 and in 32% out of 150 patients – a lower limit of normal phosphorus content in the blood. After CPB in Gr 1 phosphorus content in blood was 0.85±0.32 mmol/l and hypophosphatemia was in 53% out of 75 patients. This indicates a pronounced energy deficit in this group. In Gr 2 phosphorus level was 1.7±0.31 mmol/l and there was no hypophosphatemia. As a result, FDP as an endogenous high-energy intermediate metabolite of the glycolytic pathway leads to resistance to hemolysis, protects the erythrocyte membrane from damage and increases the energy potential of the cell during CPB.