II.

We tested the hypothesis that neuromechanical uncoupling of the respiratory system forms the mechanistic basis of dyspnea during exercise in the setting of "abnormal" restrictive constraints on ventilation (VE). To this end, we examined the effect of chest wall strapping (CWS) sufficient to mimic a "mild" restrictive lung deficit on the interrelationships between VE, breathing pattern, dynamic operating lung volumes, esophageal electrode-balloon catheter-derived measures of the diaphragm electromyogram (EMGdi) and the transdiaphragmatic pressure time product (PTPdi), and sensory intensity and unpleasantness ratings of dyspnea during exercise. Twenty healthy men aged 25.7 ± 1.1 years (means ± SE) completed symptom-limited incremental cycle exercise tests under two randomized conditions: unrestricted control and CWS to reduce vital capacity (VC) by 21.6 ± 0.5%. Compared with control, exercise with CWS was associated with 1) an exaggerated EMGdi and PTPdi response; 2) no change in the relationship between EMGdi and each of tidal volume (expressed as a percentage of VC), inspiratory reserve volume, and PTPdi, thus indicating relative preservation of neuromechanical coupling; 3) increased sensory intensity and unpleasantness ratings of dyspnea; and 4) no change in the relationship between increasing EMGdi and each of the intensity and unpleasantness of dyspnea. In conclusion, the increased intensity and unpleasantness of dyspnea during exercise with CWS could not be readily explained by increased neuromechanical uncoupling but likely reflected the awareness of increased neural respiratory drive (EMGdi) needed to achieve any given VE during exercise in the setting of "abnormal" restrictive constraints on tidal volume expansion.

No abstract

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

Delayed unions and nonunions of diaphyseal pediatric forearm fractures are exceedingly uncommon. In the past they generally have been reported in conjunction with open fracture or initial operative management of these fractures. The authors report six cases that occurred in low-energy, closed fractures initially managed with casting. The cases all occurred in teenage patients from age 13 to 16, and all cases involved the ulna. The mid-diaphysis was the most common location, and this may represent a watershed zone of perfusion with a relatively poor intraosseous blood supply. All of these patients were managed with compression plating with or without bone grafting. Three of these patients had rapid healing in an average of 2 months, while one had an inadequate radiographic record and another was lost to follow-up. The other patient had a more prolonged course to healing after surgery.