The surface of Ti6Al4V substrate was modified by two ways: micro-powder blasting and co-blast technique. Micro-powder blasting was done using Al 2 O 3 (of three different sizes) or SiC particles. Co-blast technique was done using the same particles co-blasted with hydroxyapatite (HA) particles. The morphology, roughness, deep impact and contact angle were used to characterise the surface modifications. The Ca/P atomic ratio was also determined by co-blast technique. Finally, the biocompatibility of Ti6Al4V substrate was investigated by surface modification in cell culture (osteoblast-like cell, MG63). The contact angle of Ti6Al4V substrate with surface modification is smaller than that without surface modification. The Ti6Al4V substrates by co-blast technique become more hydrophilic by co-blast technique and exhibit better cell proliferation.

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Ameloblastoma is a benign but locally invasive neoplasm of the odontogenic epithelium that tends to grow slowly in the mandible or maxilla. It can be highly destructive to the surrounding dental anatomy and can cause death by progressive spread to nearby vital structures in rare cases. Marginal resection is the most effective method of eliminating the tumor, but treatment can further contribute to oral and dental deformity and malfunction. This clinical report describes the dental rehabilitation of a young adult patient diagnosed with ameloblastoma and underwent preliminary marsupialization, segmental mandibulectomy, and fibula free flap reconstruction, followed by mandibular dental implant placements. Orthodontic and rapid palatal expansion for maxillary arch correction was also performed. The treatment goal of regaining dental function and a satisfactory appearance was accomplished.