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The fluids in horizontal wells can exhibit complicated flow behaviors with wall mass transfer, partly due to the interaction between the main flow and the radial influx along the wellbore and the completion parameters used. This paper presents a novel regression model established based on the experiment data retrieved from the available literatures to determine the apparent friction factor for a single phase wellbore flow. The proposed model has the potential to be readily applicable to different perforation parameters, such as shot phasing and shot density. Compared with other models in the same practical example which is offered by Ouyang et al., the model of this paper to calculate the wellbore pressure is applicable and reasonable. This new model can be easily incorporated into reservoir simulators or analytical reservoir and horizontal wellbore inflow coupling models.