Abstract-The increase of environmental damage in coastal and marine areas can affect the presence of marine ecosystems and fishery products such as reducing the type of fish, and causing the decline of fish obtained from the sea. This will certainly affect the socio-economy in coastal areas, especially for groups of fishermen and traders. To prevent the occurrence of environmental damage in coastal and marine areas, it is necessary to develop an early warning system. Anisakidae has the potential as an early warning system as it works as a bioindicator. This research was expost facto research with purposive sampling from two different areas in East Java, between January and March 2016. Thirty samples of groupers from coastal Probolinggo were the areas exposed to anthropogenic effects and thirty samples from coastal Tuban were selected as areas far from anthropogenic effects. The results showed that Anisakidae in groupers between the sample from coastal Probolinggo and coastal Tuban had different levels of parasitological indexes. The prevalence from coastal Probolinggo was only 10%, with the infestation rate being very low 2. It was different with the sample from coastal Tuban, with the prevalence being 80% and infestation rate 5.9%. The data was analysed with a Mann Whitney test which showed that there was a significant difference in Anisakidae infestation in groupers between the two areas. This research showed that areas exposed to anthropoghenic effects have a low infestation rate of Anisakidae if compared with areas far from anthropogenic effects. Knowing the infestation rate of Anisakidae, people and the government can measure and overcome environmental damage in coastal and marine areas.